Should Sofosbuvir and Velpatasvir (Epclusa) tablets be taken after meals?

Sofosbuvir velpatasvir (Epclusa) combination is only available through a doctor's prescribing information and needs to be taken under the supervision and guidance of a physician. The tablets can be taken orally with or without food. The sofosbuvir velpatasvir granular formulation is recommended for administration with food to increase tolerance related to palatability. Do not chew sofosbuvir and velpatasvir combination oral granules to avoid a bitter aftertaste.

Sofosbuvir and velpatasvir oral granules can be taken directly by mouth or with food. For pediatric patients under 6 years of age, oral granules should be taken with food to increase tolerance related to palatability. Sprinkle sofosbuvir and velpatasvir oral granules onto one or more spoonfuls of non-acidic soft food at or below room temperature. Examples of non-acidic foods include pudding, chocolate syrup, and ice cream. Take fosbuvir and velpatasvir combination oral granules by gently mixing them with food within 15 minutes and swallow the entire contents without chewing.

The original drug of sofosbuvir and velpatasvir has been launched in China and has entered the scope of Class B medical insurance. The domestic trade name is Bintongsha, and the specification is (400mg+100mg) * 28 tablets. The price per box is around RMB 4,000. The reimbursement ratio is different in different regions, and the price after reimbursement may be different. The original drug of sofosbuvir and velpatasvir has also been launched overseas. There are also generic drugs of sofosbuvir and velpatasvir produced in other countries. The specifications of the Bangladesh Everest Pharmaceutical Factory are (400mg + 100mg) * 28 tablets per box, and the price is around RMB 850 (the price may fluctuate due to the exchange rate). The generic drugs produced abroad are basically the same as the original drugs at home and abroad.