How long does it take to become resistant to Cabotegravir?

The development of drug resistance is a complex process involving multiple factors and is not a fixed time period. For Cabotegravir (Cabotegravir) or other antiretroviral drugs, the rate of development of resistance varies depending on individual differences, virus type, treatment regimen, medication compliance and other factors.

Here are some of the key factors that influence the rate at which resistance develops:

1.Medication compliance: Medication compliance refers to the degree to which patients take medications regularly as recommended by their doctors. If patients fail to take their medication correctly and on time, it may result in insufficient drug concentration in the body, increasing the risk of viral replication and the development of drug resistance.

2.Virus replication speed:HIVThe replication speed of HIVvirus varies depending on individual differences. Some viruses may replicate faster, leading to faster development of drug resistance.

3.Virus types: DifferentHIV strains have different sensitivities to drugs. Some viruses may be more likely to become resistant to certain drugs.

4.Treatment options: Combination antiretroviral therapy (cART) uses multiple different classes of antiretroviral drugs simultaneously to reduce the risk of the development of drug resistance. The development of resistance may be delayed by the use of effective combination treatment regimens.

5.Immune status: The status of the immune system may also influence the development of drug resistance. The stronger a patient's immune function, the more likely they are to control viral replication and reduce the chance of drug resistance developing.

It is important to emphasize that drug resistance is a possible risk regardless of the drug used to treat HIV. To minimize the development of drug resistance, patients should use drugs strictly according to their doctor's recommendations and treatment regimen, and undergo regular monitoring and follow-up. If signs of treatment failure or increased viral replication are found, report to the doctor promptly so that the treatment plan can be adjusted. Early detection and management of drug resistance can help ensure that patients continue to benefit from antiretroviral treatment, delay the progression of HIV disease, and reduce the risk of transmission.

Cabotegravir is not currently on the market in China, so patients cannot purchase it domestically and need to purchase cabotegravir through overseas channels. Foreign cabotegravir only has original drugs, mainly European original drugs, and the price is very high, about 16,000 yuan.