What is the difference between Capmatinib and Savolitinib? Which one is better?

Capmatinib and Savolitinib (Savolitinib) are drugs that belong to the tyrosine kinase inhibitor (TKI) class and are used to treat specific subpopulations of patients with non-small cell lung cancer (NSCLC). They differ primarily in their targets of action and research evidence.

Target:

The main target of capmatinib is METkinase, especially for MET exon 14 skipping mutations in NSCLC patients. METExon 14 skipping mutations lead to abnormal activation of MET kinase. Capmatinib inhibits the activity of MET kinase and blocks abnormal signaling, thereby slowing down or inhibiting the proliferation of cancer cells.

Savotinib's main target is also METkinase. It is mainly used to treat MET exon 14 skipping mutations NSCLC patients. Like capmatinib, saivotinib interferes with the growth and spread of cancer cells by inhibiting the activity of MET kinase.

Research Evidence:

Capmatinib has shown a certain degree of therapeutic efficacy in some clinical trials and has been approved by relevant regulatory agencies for the treatment of METexon14 advanced NSCLC patients with skipping mutations.

Savotinib has also shown efficacy in some clinical trialsMETExon14Skipping mutationNSCLCPotential therapeutic effect in patients, but at the date of my knowledge (

Which drug is better depends on the patient's specific condition, medical history, and doctor's recommendations. Treatment selection should be individualized and based on the patient's disease characteristics and physical condition. If you or someone you know needs information about a specific medication or is faced with a treatment decision, it is strongly recommended to consult a professional healthcare provider for the best advice.

Capmatinib is not currently on the market in China, so patients cannot purchase it domestically. Capmatinib abroad is divided into original drugs and generic drugs. The original drug is mainly the original drug from Novartis, with a price of about 35,000 yuan and a specification of 200mg*60; the price of generic drugs is very cheap, mainly Laos generic drugs, with a price of about 3,000 to 4,000 yuan. The ingredients of original drugs and generic drugs are basically the same. Savotinib is a domestically produced drug and can be purchased at local pharmacies.