Will taking sofosbuvir and velpatasvir (Epclusa) affect menstruation?

Vaginal bleeding during menstruation has been reported in only a few people taking sofosbuvir and velpatasvir (Epclusa) combination. The Phase IV clinical study analyzed the sofosbuvir-velpatasvir combination and experienced vaginal bleeding during menstruation. Created based on reports from many people who experienced side effects while taking the sofosbuvir-velpatasvir combination from the U.S. Food and Drug Administration (FDA), the Phase IV trial was used to detect adverse outcomes of the drug and monitor the drug's effectiveness in the real world.

Women are half as likely as men to be infected with hepatitis C virus (HCV), and the female hormone estrogen works with liver cells to protect the liver from HCV. But during menopause, when estrogen levels drop and menstrual periods no longer occur, this defense declines. This means that HCV causes more liver damage as you age. Some hepatitis C treatments can cause birth defects or miscarriage. The virus has been cleared for at least 6 months before trying to get pregnant. Doctors may not treat hepatitis C during pregnancy.

The original drug of sofosbuvir and velpatasvir has been launched in China and has entered the scope of Class B medical insurance. The domestic trade name is protonsa, and the specification (400mg+100mg)*28 tablets is priced at about 4,000 yuan per box. The original drug of sofosbuvir and velpatasvir has also been launched overseas. There are also generic drugs of sofosbuvir and velpatasvir produced in other countries. The price of the specification (400mg + 100mg) * 28 tablets produced by Everest Pharmaceutical Factory in Bangladesh is about 850 yuan per box (the price may fluctuate due to the exchange rate). The generic drugs produced abroad are basically the same as the original drugs at home and abroad.