What are the side effects of sirolimus?

Sirolimus (sirolimus) is suitable for preventing organ rejection in patients over 13 years old who have received kidney transplants, and is also suitable for the treatment of patients with lymphangioleiomyomatosis (LAM). Treatment should be started by and under the guidance of a qualified transplant expert. Available by prescription only, sirolimus is available as an oral solution (1 mg/ml) and tablets (0.5, 1 and 2 mg).

The most common (≥30%) sirolimus adverse reactions observed in clinical studies for the prevention of organ rejection in renal transplant recipients are peripheral edema, hypertriglyceridemia, hypertension, hypercholesterolemia, increased creatinine, constipation, abdominal pain, diarrhea, headache, pyrexia, urinary tract infection, anemia, nausea, arthralgia, pain, and thrombocytopenia. The most common (≥20%) adverse reactions observed in clinical studies of rapamycin in the treatment of LAM were stomatitis, diarrhea, abdominal pain, nausea, nasopharyngitis, acne, chest pain, peripheral edema, upper respiratory tract infection, headache, dizziness, myalgia, and hypercholesterolemia.

SirolimusThe original drug has been launched in China and has entered the scope of Class B medical insurance. SpecificationsThe price of each box of 1mg*10 tablets is about 400 yuan. The domestic drug is only available to patients with anti-rejection reactions in organ transplantation. Patients who do not meet the conditions may not be able to purchase this drug. The original sirolimus drug has also been launched overseas. The price of the Turkish version of Specifications1mg*100 tablets per box is around RMB 2,000 (the price may fluctuate due to exchange rates). The ingredients of the original drugs marketed in China are basically the same as those of foreign original drugs. Currently, there are no generic sirolimus drugs produced in other countries.