Crizotinib dosage and usage

Crizotinib (Crizotinib) is a tyrosine kinase inhibitor used to treat certain types of malignancies. Proper planning of its dosage and usage is crucial to therapeutic efficacy and patient safety. The dosage and usage of crizotinib will be introduced in detail below, including indications, dosage selection, route of administration, medication time and precautions.

1. Indications: Crizotinib is mainly suitable for the treatment of the following two malignant tumors:

1.Positive epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer (NSCLC): used to treat carriers patients with late-stage NSCLC with span>ALK fusion gene or ROS1 rearrangement.

2.Musculoskeletal sarcoma (IMT): For the treatment of adult patients with local progression, local recurrence, or distant metastasis of kinase-rich lesions (KDR, PDGFRA, PDGFRB).

2. Dose selection: The dose of crizotinib should be determined according to the patient's specific situation and adjusted under the guidance of a professional doctor. Typically, the dosage is as follows:

1.Non-small cell lung cancer (NSCLC): It is recommended to take crizotinib capsules 250mg orally daily for continuous use, preferably after meals.

2.Musculoskeletal sarcoma (IMT): It is recommended to take crizotinib capsules 300mg orally daily for continuous use, preferably after meals.

.For elderly patients, patients with impaired liver and kidney function, and children, the dosage needs to be adjusted according to their physical conditions and administered under the guidance of a doctor.

3. Route of administration: Crizotinib is an oral drug and is supplied in capsule form. Taking it orally after meals can reduce the occurrence of some gastrointestinal adverse reactions and help improve patient compliance.

4. Medication time: The medication time of crizotinib should be based on the doctor’s prescription instructions, and patients should be treated strictly in accordance with the prescribed dosage and frequency of medication. Generally, crizotinib is a long-term treatment until disease progression or adverse effects are intolerable.

5. Precautions: When using crizotinib, patients and doctors need to pay attention to the following matters:

1.Before treatment, the ALK or ROS1 fusion gene should be tested to ensure that the patient is suitable for crizotinib treatment.

2.During treatment, the patient's electrocardiogram, liver function, vision, etc., as well as other important laboratory indicators, need to be regularly monitored to ensure monitoring of physical condition and evaluation of treatment effects.

3.During use, patients may experience common side effects such as fatigue, nausea, and vomiting, and may also cause serious adverse reactions such as pneumonia, tachycardia, and blurred vision. If there are any abnormalities, they should be reported to the doctor in time.

4.Crizotinib may interact with other drugs, especially drugs that are strongCYP3Ainhibitors and inducers. Concomitant use with these drugs should be avoided during treatment.

5.Crizotinib is contraindicated in pregnant and lactating women and effective contraceptive measures must be taken during treatment.

Overall, crizotinib is an important anti-tumor drug with significant efficacy in patients with NSCLC carrying ALK fusion genes or ROS1 rearrangements, as well as patients with musculoskeletal sarcomas. However, when using crizotinib for treatment, reasonable planning and monitoring by professional doctors are required. Patients must follow the doctor's instructions, cooperate with treatment and have regular follow-up visits to ensure the maximum treatment effect and reduce the occurrence of adverse reactions. If you have any questions or discomfort, please consult a professional doctor in time.

Crizotinib is currently on the market in China and is included in medical insurance. Patients can purchase it domestically, and the price is around 6,000~12,000 yuan. Since the price of medical insurance policies varies greatly across regions, please consult your local pharmacy or medical insurance bureau for specific prices. There are original and generic versions of crizotinib available abroad. The original version is mainly Pfizer’s original drug, and the price is around 11,000 yuan. Generic drugs are mainly from Bangladesh and Laos. Due to different pharmaceutical manufacturers and drug specifications, generic drugs cost around 2,700~3,000 yuan. Moreover, the ingredients of foreign original drugs and generic drugs are basically the same as those of domestic drugs.