How to take Selpercatinib

The recommended weight-based dose of Selpercatinib is 120 mg for patients less than 50 kg and 160 mg for patients 50 kg or more. Selpercatinib is taken orally twice daily until disease progression or unacceptable toxicity occurs. Do not take a missed dose unless it is more than 6 hours before your next scheduled dose. Severe hepatic impairment: For patients with severe hepatic impairment taking 120 mg or 160 mg, the dose of selpatinib should be reduced to 80 mg orally twice daily.

If patients experience adverse reactions after taking serpatinib, the dose should be adjusted. Patients who are less than 50kg will be reduced to 80mg orally twice daily for the first time, 40mg orally twice a day for the second time, and 40mg orally once a day for the third time; patients who are 50kg or above will be reduced to 120mg orally twice a day for the first time, 80mg orally twice a day for the second time, and 40mg orally twice a day for the third time. Patients who cannot tolerate three dose reductions should permanently discontinue serpatinib.

The original drug Serpatinib has not yet been launched in China, so it is not covered by medical insurance. Domestic patients cannot yet purchase this drug. Serpatinib marketed overseas The original drug has a US version and a European version. The price of the US version is about 150,000 yuan per box of 80mg*60 pills. The price of the European version of 80mg*56 pills per box is about 21,000 yuan (the price may fluctuate due to the exchange rate), which is expensive. There are also serpatinibgeneric drugs produced abroad. The specification produced by a Bangladesh pharmaceutical factory is 40mg*30 pills per box and the price is about 4,300 yuan (the price may fluctuate due to the exchange rate). The ingredients of the generic drugs are basically the same as those of the original drug.