The role of Defibrotide/Defibrotide

Defibrotide/Defibrotide (Defibrotide) is a drug mainly used to treat venous thrombophlebitis syndrome (veno-occlusive disease, VOD). VOD is a rare but serious blood vessel disease that usually occurs after a hematopoietic stem cell transplant (such as a bone marrow transplant). This disease causes damage to small blood vessels in the liver, causing blood circulation disorders, inflammatory reactions, and thrombosis, which may lead to liver insufficiency, which may even be life-threatening in severe cases.

1.Defibrotide/Defibrotide sodium works through its special chemical structure and multiple mechanisms, mainly focusing on the following aspects:

Anticoagulant effect: Defibrotide/Defibrotide sodium can increase blood fluidity and prevent the formation of thrombus. It reduces the risk of blood clots in the veins by regulating the levels of clotting factors and fibrin, reducing the blood's tendency to clot. This is important to prevent thrombosis that may occur in VOD patients.

2.Anti-inflammatory effect: Defibrotide/Defibrotide sodium can reduce the inflammatory response of vascular endothelial cells and help maintain the normal function of blood vessels. Injury and inflammation of vascular endothelial cells are one of the important factors in the occurrence and progression of VOD. Defibrotide/Defibrotide sodium helps protect vascular health by reducing this inflammatory response.

3.Improve blood circulation: Defibrotide/Defibrotide sodium can dilate blood vessels, increase blood flow, and promote blood flow in the liver. This helps reduce the risk of blood clots and improves blood supply to the liver, thereby reducing the likelihood of liver damage caused by VOD.

4.Maintain endothelial cell health: Endothelial cells are the main component of blood vessel walls and are key to regulating blood circulation and inflammatory responses. Defibrotide/Defibrotide sodium helps maintain the health of endothelial cells and reduce their damage, thereby maintaining normal vascular function.

In short, defibrotide/As a multifunctional drug, defibrotide sodium plays a positive role in the treatment of venous thrombophlebitis syndrome (VOD) through its anticoagulant, anti-inflammatory and improved blood circulation effects. However, when using defibrotide/defibrotide sodium, it is still necessary to follow the advice and supervision of your doctor to ensure safe and effective treatment.

Defibrotide/Defibrotide sodium is not currently on the market in China, and it is not included in medical insurance. Therefore, patients cannot purchase it domestically and need to purchase defibrotide sodium through foreign purchasing channels. /Defibrotide sodium. Overseas, defibrinoside/Defibrotide sodium only has the original drug, and there are no generic drugs. The cheaper original drug is the Turkish original drug, which costs about 21,000 yuan, which is still very high.