How long does it take to become resistant to Sotorasib?

Currently, specific knowledge of resistance to sotorasib (Sotorasib) remains limited because the drug is a relatively new targeted therapy. If a patient is being treated with sotorazepam, it is recommended to work closely with their physician for regular examinations and follow-up visits so that any possible signs of resistance can be identified early and the treatment plan can be adjusted based on the specific situation.

It has been observed in some early clinical trials that although sotoracib has shown efficacy in patients with non-small cell lung cancer (NSCLC) with KRAS G12C mutations, some patients may develop drug resistance after receiving treatment for a period of time. This means that tumor cells may gradually develop mechanisms to bypass the effects of sotoraxib, rendering the treatment ineffective. Long-term follow-up studies of this drug are currently underway to assess the durability of its effects and possible resistance issues. In addition, other research efforts are underway to explore how to overcome or delay the development of drug resistance.

SotoracibThe original drug has not yet been launched in China, so it is not covered by medical insurance. Domestic patients cannot yet purchase this drug. The price of Hong Kong original research versionsotorasibuSpecifications120mg*240 tablets is about RMB 80,000, and the European original research version 120mg*240 tablets is priced at about RMB 44,040 (the price may fluctuate due to the exchange rate), which is relatively expensive. There are also cheaper generic drugs for sale in other countries. The specifications of the Laos Element Pharmaceutical Factory are 120mg*56 tablets and the price is around 4800 yuan (the price may fluctuate due to the exchange rate). The price is relatively cheap. The ingredients of foreign generic drugs are basically the same as the original drugs.