Instructions for Defibrotide/Defibrotide

1. Indications:

Fibroside is an anticoagulant and thrombolytic drug mainly used for the following indications:

1.Hepatic veno-occlusive disease (VOD): Defibrotide/Defibrotide sodium is used to treat hepatic veno-occlusive disease caused by hematopoietic stem cell transplantation. It can help reduce related symptoms and improve patient survival rates.

2.Thrombotic microangiopathy (TMA): used to treat patients with heparin-induced thrombocytopenia (HIT) combined with thrombotic microangiopathy.

2. Mechanism of action and pharmacology:

Fibrosides are a diverse group of drugs whose mechanisms of action are not fully understood. It mainly works through the following aspects:

1.Anticoagulant effect: Fibrin can inhibit platelet aggregation and reduce the release of coagulation factors by platelets, thereby slowing down the thrombosis process.

2.Thrombolytic effect: Fibrinoside can increase the release of plasminogen activator (t-PA) and promote the dissolution of fibrin, thus helping to dissolve thrombus.

3.Anti-inflammatory effect: Fibrin can reduce inflammatory response, inhibit leukocyte adhesion and migration, thereby protecting endothelial cells and blood vessels from damage.

4.Cytoprotective effect: Fibrin can promote the repair and regeneration of endothelial cells and enhance the stability of blood vessel walls.

3. Dosage and usage:

Please use it strictly in accordance with the doctor's advice and the dosage instructions in the drug instructions. Dosage and duration of treatment will be based on the patient's specific condition and the disease being treated. Usually, fibrin is administered intravenously, and the time and speed of administration must be followed as directed by your doctor. Recommended dose:6.25mg/kg(Dose is calculated based on the patient's baseline weight), intravenous infusion, continuous infusion 2 hours; once every 6 hours; continuous treatment for at least 21 days, if the patient's related symptoms have not resolved, continue treatment until symptoms resolve or up to 60 days.

4. Side effects:

Fiber may cause some side effects, which vary from person to person, including but not limited to:

1.Bleeding: Bleeding may occur in the skin, mucous membranes, gastrointestinal tract and other parts of the body.

2.Hypotension: may cause dizziness, fatigue and other symptoms.

3.Allergic reactions: such as rash, urticaria, difficulty breathing, etc.

4.Abnormal liver function: Abnormal liver function may occasionally occur.

5. Warnings and precautions:

1.Before using fiber glycosides, you should inform your doctor of your allergy history, especially for patients who are allergic to fiber glycoside ingredients.

2.Patients with severe bleeding symptoms should use fibrin with caution or avoid using it.

3.Pregnant women, lactating women and children should consult a doctor before use.

4.The patient's vital signs and blood coagulation indicators need to be closely monitored during intravenous injection.

5.If severe allergic reactions, bleeding and other adverse reactions occur, you should stop taking the medicine immediately and seek medical treatment.

6. Contraindications:

1.This drug is prohibited for patients who are allergic to fiber glycosides.

2.This drug is contraindicated in patients with severe bleeding symptoms.

7. Drug interactions:

There may be other drug interactions while using fibrin. Please tell your doctor about other drugs you are taking, including prescription drugs, over-the-counter drugs, and supplements, to avoid unnecessary drug interactions.

8. Medication for special groups:

1.Pregnant and lactating women should use fiber glycosides under the guidance of a doctor, because the safety for these groups has not yet been fully determined.

2.Children’s medication should follow the doctor’s recommendations and dosage.

9. Listing and price situation:

Defibrinoside/Defibrotide SodiumIt is not currently on the market in China, let alone covered by medical insurance, so patients cannot purchase it domestically and need to purchase it through foreign purchasing channelsDefibrotide Sodium/Defibrotide Sodium. OverseasDefibrinoside/Defibrotide Sodium only has original drugs and no generic drugs. The cheaper original drugs are Turkish original drugs, which cost about 21,000 yuan, which is still very high.

Fibroside is an anticoagulant and thrombolytic drug indicated for conditions such as hepatic veno-occlusive disease. Its mechanism of action mainly includes anticoagulation, thrombolysis, anti-inflammation and cell protection. Medication must be taken in strict accordance with the doctor's recommendations and drug instructions, especially in terms of side effects, contraindications, warnings and precautions. It is necessary to consult a doctor while using fiber glycosides to prevent drug interactions and ensure medication safety for special populations.