What kind of medicine is Sonidegib?

Sonidegib is an oral small molecule that acts as a selective antagonist of the SMO receptor, a G protein-coupled receptor-like structure that is crucial for the correct function of the HH signaling pathway. Solidegibhas shown dose- and exposure-dependent inhibition of GLI homolog 1 expression in tumors and normal skin biopsies and is currently used to treat advanced basal cell carcinoma (BCC) in adults at a daily dose of 200 mg.

Basal cell carcinoma(BCC) accounts for nearly 80% of skin cancers, and its health care workload burden is considerable in dermatology. Although most basal cell carcinomas are small, well-circumscribed tumors that can be treated surgically or conservatively, in a small proportion of patients, basal cell carcinomas can progress to advanced stages, including locally advanced basal cell carcinoma. Clinicians' goal in treating basal cell carcinoma should be to adopt the correct treatment approach at the time of diagnosis, and different guidelines propose treatment strategies to prevent recurrence or disease progression. For basal cell carcinoma that is unresectable and cannot be treated with radiotherapy, the first-line pharmacotherapy is a hedgehog-GLI (HH) pathway inhibitor. Solidegibhas been approved by the U.S. Food and Drug Administration(FDA) and the European Medicines Agency (EMA) as a first-line treatment for adult patients with locally advanced basal cell carcinoma.

Solidagen is a new type of drug for treating diseases. Although the original drug Solidagen has been marketed in China, it has not yet entered the scope of medical insurance, and its price has not yet been determined. The Original drug Solidaget listed overseas, European version specificationsThe price per box of 200mg*30 tablets is around RMB 46,000 (the price may fluctuate due to the exchange rate), which is relatively expensive. The ingredients of the two drugs are basically the same. There is currently no generic version of Solidaget produced and marketed. For specific prices and drug information, please consult Yaodei Medical Consultants.