Where to buy Sonidegib

Hedgehog inhibitors are promising alternative treatments for patients with advanced basal cell carcinoma. Sonidegib (Sonidegib) is an oral SMO antagonist indicated for the treatment of adult patients with locally advanced basal cell carcinoma (laBCC) who have experienced recurrence after surgery or radiation therapy or who are not candidates for surgery or radiation therapy. Several studies and randomized controlled trials have been conducted to evaluate the efficacy, safety and tolerability of this new molecule, which has shown a good response rate (44%). Grade 1-2 adverse events have also been reported.

Basal cell carcinoma(BCC) is the most common skin cancer with increasing incidence worldwide, accounting for 80% of non-melanoma skin cancer cases. Solidegibis an oral small molecule inhibitor of the hedgehog pathway. It acts by binding to and inhibiting the activity of the SMO transmembrane protein, thereby completely inhibiting GLI and tumor regression18]. In vitro studies and animal models have demonstrated the inhibitory effect of Solidagib on Hh signaling and anti-tumor activity; several preclinical studies have shown that this molecule has high tissue permeability, including blood and brain barriers, and good oral bioavailability.

Solidagen is a new type of drug for treating diseases. Although the original drug Solidagen has been launched in China, it has not yet entered the scope of medical insurance. Its price has not yet been determined, and domestic patients cannot yet purchase this drug. The price of Solidegib Original drug, European version specifications200mg*30 capsules per box listed overseas is around RMB 46,000 (the price may fluctuate due to the exchange rate), which is relatively expensive. The ingredients of the two drugs are basically the same. When purchasing this drug overseas, you need to choose through formal channels. Currently, there are no generic drugs of Solidagen produced and put on the market. For specific price and drug information, please consult Yaode Medical Consultant.