Are there generic versions of dolutegravir/lamivudine/tenofovir (Viropil, DTG/3TC/TDF)?

Dolutegravir/Lamivudine/Tenofovir, also known as Viropil (Viropil), is a combination drug used to treat human immunodeficiency virus (HIV) infection. It consists of three different drugs, each with a different mechanism of action, which together help inhibit viral replication, reduce the amount of virus in the body, thereby maintaining immune system function and delaying the progression of HIV infection.

Dolutegravir/Lamivudine/Tenofovir (Viropil, Viropil, DTG/3TC/TDF) is not currently available in the country, so it cannot be purchased domestically and needs to be purchased through foreign channels. The cheaper ones abroad are Indian generic drugs, which cost about 450 yuan.

Specifically, the composition of dolutegravir/lamivudine/tenofovir is as follows:

1.Dolutegravir (Dolutegravir, DTG): Dolutegravir belongs to the integrase chain terminator (INSTI) drug class. By inhibiting the activity of HIV integrase, it prevents the virus from integrating its genetic material into the host cell's DNA, thus preventing the virus from replicating and propagating in the host cell.

2.Lamivudine (Lamivudine, 3TC): Lamivudine is a nucleoside analog reverse transcriptase inhibitor (NRTI). It can inhibit the activity of HIV reverse transcriptase and prevent the virus from transcribing its RNA into DNA, thereby preventing the virus from replicating within the host cell.

3.Tenofovir (Tenofovir Disoproxil Fumarate, TDF): Tenofovir is also a nucleoside analog reverse transcriptase inhibitor (NRTI). It works synergistically with lamivudine to interfere with viral replication by inhibiting HIV reverse transcriptase.

The combined use of these three drugs can interfere with the life cycle of HIV from different angles, ultimately inhibiting viral replication and reducing viral load, thereby slowing down the damage to the immune system caused by HIV infection.