What are the adverse reactions of Dolutegravir Sodium?

Dolutegravir Sodium is an antiretroviral drug used to treat human immunodeficiency virus (HIV) infection. Although it plays an important role in HIV treatment, like all drugs, dolutegravir sodium may cause some adverse reactions. Both patients and doctors need to fully understand the possible adverse reactions when using dolutegravir sodium so that they can take timely measures or adjust the treatment plan.

The following are possible adverse reactions of dolutegravir sodium, divided into common, more common and rare categories:

Common adverse reactions (affecting more than 1% of patients):

1.Headache: Patients may experience headache early in treatment or during long-term use of dolutegravir sodium.

2.Weakness and fatigue: This may be one of the common side effects, but it usually lessens over time with treatment.

3.Nausea and vomiting: Some patients may experience nausea and vomiting while taking dolutegravir sodium. This may affect the patient's appetite and nutritional intake.

4.Gastrointestinal discomfort: including diarrhea, abdominal pain, heartburn and other symptoms. These symptoms may be more noticeable early in treatment but may lessen over time.

More common adverse reactions (affecting less than1% of patients):

1.Skin rash: Some patients may experience skin reactions such as skin itching, erythema, and rash. These symptoms are usually not serious but still require close monitoring.

2.Dizziness: Dizziness may occur when using dolutegravir sodium and may be related to a drop in blood pressure.

3.Insomnia: Some patients may have difficulty falling or staying asleep at night, resulting in symptoms of insomnia.

4.Elevated liver enzymes: During the use of dolutegravir sodium, some patients may experience an increase in liver function indicators, which requires regular monitoring.

5.Muscle pain: Some patients may experience muscle pain or muscle weakness.

Rare adverse reactions (affecting less than0.1% of patients):

1.Severe allergic skin reaction: This may include severe allergic reactions such as hives, edema, and skin peeling, and requires immediate medical attention.

2.Pancreatitis: Some patients may experience symptoms of pancreatitis, such as abdominal pain, nausea, vomiting, etc. This is a serious adverse reaction and requires prompt treatment.

3.Abnormal renal function: In rare cases, dolutegravir sodium may affect renal function, leading to abnormal renal function.

4.Blood problems: In rare cases, dolutegravir sodium may affect the hematopoietic function of the blood, leading to anemia, thrombocytopenia and other problems.

It is worth noting that different patients may have different tolerance and adverse reactions to dolutegravir sodium. For those patients who experience adverse reactions, doctors may consider adjustments to their treatment regimen, including adjusting the dose or choosing a different combination of drugs. Therefore, it is crucial to maintain close communication and monitoring with your doctor while using dolutegravir sodium.

In short, dolutegravir sodium, as an important drug inHIV treatment, can effectively control virus replication and improve patients' quality of life. However, during use, both patients and doctors should pay close attention to potential adverse reactions and make appropriate treatments and adjustments based on the patient's specific conditions. Only by using dolutegravir sodium rationally under the guidance of a professional doctor can its therapeutic effect be maximized and possible adverse effects reduced.

Dolutegravir sodium has been launched in China, but it has not yet been included in medical insurance. Patients can purchase it in hospital pharmacies at a price of around 1,200 yuan. Please consult the local hospital pharmacy for specific prices. Dolutegravir sodium is cheaper abroad, mainly Indian generic drugs, with a price of around 350 yuan, and the ingredients of domestic original drugs and foreign generic drugs are basically the same.