What is Osimertinib?

Osimertinib (Osimertinib) is used to treat abnormal non-small cell lung cancer (NSCLC) that is positive for the abnormal "EGFR" gene. Your doctor will test you for this gene. Osimertinib is sometimes given when the cancer has spread to other parts of the body (metastatic) or may come back after surgery, usually once a day with or without food. To make swallowing easier, you can place the tablets in a glass with 2 ounces of water. Stir until the tablets are mostly dissolved, then drink the mixture immediately. Add 4-8 ounces of water to the glass, shake gently, and drink immediately.

Osimertinib is an irreversible EGFR TKI designed to inhibit EGFR sensitization and EGFR T790M resistance mutations. It crosses the blood-brain barrier and is known to be active against central nervous system damage. Osimertinib received accelerated approval for this indication in 2015 after achieving an overall response rate (ORR) of 59% in 411 patients in two single-arm clinical trials.

OsimertinibThe original drug has been launched in China and has entered the scope of medical insurance. Its name is Osimertinib Mesylate Tablets. The reimbursement ratio is different in different regions, and the price after reimbursement may be different. SpecificationThe price of 80mg*30 tablets per box is around RMB 5,000, which is relatively expensive. The original drug of Osimertinib has also been launched overseas, and there are also generics of Osimertinib produced in other countries. For example, the price of 80mg*30 tablets per box produced by Bangladesh Yaopin International is around RMB 850 (the price may fluctuate due to the exchange rate). The price is relatively cheap. The ingredients of the generic Osimertinib and the original drug are basically the same.