What are the side effects of Regorafenib?

Regorafenib(Regorafenib) is indicated for the treatment of patients with metastatic colorectal cancer (CRC) who have received prior fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, anti-VEGF therapy, and anti-EGFR therapy (in the case of RAS field). type), and is also indicated for the treatment of patients with locally advanced, unresectable or metastatic gastrointestinal stromal tumors (GIST) who have been previously treated with imatinib mesylate and sunitinib malate, and for the treatment of patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib.

In randomized placebo-controlled trials, the most commonly observed adverse drug reactions (≥20%) in patients receiving regorafenib (≥20%) were pain (including gastrointestinal and abdominal pain), HFSR, asthenia/fatigue, diarrhea, decreased appetite/food intake, hypertension, infection, dysphonia, hyperbilirubinemia, pyrexia, mucositis, weight loss, rash, and nausea. Adverse reactions found during post-approval use of regorafenib include allergic reactions, nephrotic syndrome, heart failure, arterial (including aorta) aneurysms, dissections and ruptures.

RegofenibThe original drug has been launched in China and has entered the scope of Class B medical insurance. Reimbursement is limited to patients who meet the indications. SpecificationThe price of each box of 40mg*28 tablets is around RMB 5,000. The reimbursement ratio is different in different regions, and the price after reimbursement is different. The Turkish version of regorafeniboriginal drug specifications 40mg*28 tablets sold overseas is priced around RMB 6,400 per box (the price may fluctuate due to exchange rates). There are also generic regorafenib drugs produced in other countries, and their drug ingredients are basically the same as those of the original drug. The price of a box of 40mg*90 tablets produced by a Bangladesh pharmaceutical factory is around 2,900 yuan (the price may fluctuate due to exchange rates).