Efficacy and effects of Regorafenib

Regorafenib (Regorafenib) was compared with placebo (a dummy treatment) in a major study involving 760 patients with metastatic colorectal cancer who had progressed after standard treatment. The primary efficacy endpoint was overall survival (the length of time patients lived). All patients also received supportive care, including pain medication and treatment for infections. The study showed that regorafenib improved survival rates, with patients who received the treatment surviving an average of 6.4 months.

In another major study, regorafenib was compared with placebo in 199 patients with gastrointestinal stromal tumors that had spread or were inoperable and who also received best supportive care. Supportive care includes treatments such as pain relief, antibiotics, and blood transfusions, which can help the patient but do not treat the cancer. The study showed that supportive care with regorafenib was effective in prolonging patients' survival without worsening of the disease. Patients treated with regorafenib lived an average of 4.8 months without disease progression.

Regofenib was compared with placebo in a major study involving573 patients with hepatocellular carcinoma whose disease progressed after treatment with sorafenib. All patients also received supportive care. The study showed that regorafenib increased overall patient survival, with patients treated with regorafenib surviving an average of 10.6 months.

RegofenibThe original drug has been launched in China and has entered the scope of Class B medical insurance. Reimbursement is limited to patients who meet the indications. SpecificationThe price of each box of 40mg*28 tablets is around RMB 5,000. The reimbursement ratio is different in different regions, and the price after reimbursement is different. The Turkish version of regorafeniboriginal drug specifications 40mg*28 tablets sold overseas is priced around RMB 6,400 per box (the price may fluctuate due to exchange rates). There are also generic regorafenib drugs produced in other countries, and their drug ingredients are basically the same as those of the original drug. The price of a box of 40mg*90 tablets produced by a Bangladesh pharmaceutical factory is around 2,900 yuan (the price may fluctuate due to exchange rates).