How much does a bottle of Regorafenib cost?

Regorafenib(Regorafenib) is a diphenylurea oral multikinase inhibitor indicated for the treatment of patients with metastatic colorectal cancer, unresectable, locally advanced or metastatic gastrointestinal stromal tumors, and hepatocellular carcinoma. Structurally equivalent to sorafenib, it targets multiple kinases involved in angiogenesis and tumor growth-promoting pathways.

Preclinical studies have shown that regorafenib targets kinases involved in signaling pathways that drive tumorigenesis, cancer spread and maintenance of the tumor microenvironment. Regofenib is the first drug to actively show a significant survival advantage as a second-line treatment for patients with unresectable hepatocellular carcinoma (HCC) who have failed previous first-line treatment with sorafenib. Recent evidence suggests that its antitumor efficacy is due to comprehensive inhibition of tumor neoangiogenesis and proliferation and immunomodulatory effects on the tumor microenvironment, which play a crucial role in tumor development, an efficacy that led to the approval of regorafenib as a second-line treatment.

RegofenibThe original drug has been launched in China and has entered the scope of Class B medical insurance. Reimbursement is limited to patients who meet the indications. SpecificationThe price of each box of 40mg*28 tablets is around RMB 5,000. The reimbursement ratio is different in different regions, and the price after reimbursement is different. The Turkish version of regorafeniboriginal drug specifications 40mg*28 tablets sold overseas is priced around RMB 6,400 per box (the price may fluctuate due to exchange rates). There are also generic regorafenib drugs produced in other countries, and their drug ingredients are basically the same as those of the original drug. The price of a box of 40mg*90 tablets produced by a Bangladesh pharmaceutical factory is around 2,900 yuan (the price may fluctuate due to exchange rates).