Why Regorafenib is not the first choice for liver cancer

Regorafenib(Regorafenib) has a triple mechanism of action, acting on targets involved in regulating angiogenesis, cell proliferation and tumor stroma. These targets include vascular endothelial growth factor receptor 1-3 (VEGFR1-3), angiopoietin 1 receptor (TIE2), fibroblast growth receptors (FGFRs), platelet-derived growth factor receptor beta (PDGFR)-beta, oncogenic kinases KIT and RET, and intracellular signaling molecules, including those fibrosarcoma-accelerating (c-RAF/RAF-1) kinase, B-RAF, and BRAF V600E mutants.

Regofenibhas anti-immunosuppressive properties and promotes anti-tumor immunity. Regofenibshows an important role in enhancing anti-tumor immunity by regulating macrophages and increasing the proliferation and activation of CD8+ T cells. Tumor-associated macrophages (TAMs) are key factors in leukocyte infiltration and promote the growth, development and migration of tumor cells. The role of TAMs in carcinogenesis is well documented in several tumor types, including liver cancer. Regofenibinhibits the colony-stimulating factor 1 receptor (CSF1R), which is critical for macrophage differentiation and survival, and reduces tumor infiltration of macrophages.

RegofenibThe original drug has been launched in China and has entered the scope of Class B medical insurance. Reimbursement is limited to patients who meet the indications. SpecificationThe price of each box of 40mg*28 tablets is around RMB 5,000. The reimbursement ratio is different in different regions, and the price after reimbursement is different. The Turkish version of regorafeniboriginal drug specifications 40mg*28 tablets sold overseas is priced around RMB 6,400 per box (the price may fluctuate due to exchange rates). There are also generic regorafenib drugs produced in other countries, and their drug ingredients are basically the same as those of the original drug. The price of a box of 40mg*90 tablets produced by a Bangladesh pharmaceutical factory is around 2,900 yuan (the price may fluctuate due to exchange rates).