How Everolimus works

Everolimus (Everolimus) is a targeted therapy drug whose mechanism of action mainly involves inhibiting the mammalian target of rapamycin (mTOR) signaling pathway. mTOR is an intracellular signaling protein that plays a key role in multiple biological processes such as cell growth, proliferation, metabolism, and survival. Everolimus affects the normal functions of cells by interfering with the mTOR signaling pathway, thereby exerting an inhibitory effect on cancer cells and other abnormal cells.

The following are the main aspects of everolimus’ mechanism of action:

1.Inhibition of cell growth and proliferation:mTOR signaling pathway plays an important role in promoting cell growth and proliferation. Everolimus can inhibit the activity of the mTOR signaling pathway and block the phosphorylation of related proteins, thereby slowing down cell growth and division.

2.Inhibition of blood supply and nutrient supply: mTOR signaling pathway is also involved in regulating angiogenesis and nutrient supply of cells. The effect of everolimus can affect the blood supply of tumors and reduce the supply of nutrients, thus limiting the growth and development of tumors.

3.Immune regulation: mTOR signaling pathway also plays an important role in the immune system, affecting the differentiation and function of immune cells. The inhibitory effect of everolimus may affect the function of immune cells, thereby playing an immunosuppressive role in cases such as transplant rejection.

4.Cell survival regulation: mTOR signaling pathway also regulates cell survival and apoptosis. By interfering with this signaling pathway, everolimus can promote apoptosis in certain cancer cells, thereby reducing tumor burden.

Everolimus has been approved for marketing in my country, and everolimus has been included in the national medical insurance. The price is about 4000~5000 yuan. It takes about 2 to take everolimus a month.Boxes are available. For specific prices and medical insurance reimbursement policies, please consult the local hospital pharmacy or medical insurance bureau. The cheaper ones abroad are mainly Indian generic drugs, the price is around 700~1,500yuan, and the ingredients of the drugs are basically the same as those in China.