Can I take Regorafenib while taking cephalosporins?

Regorafenib (Regorafenib) and cephalosporins are in different drug classes. Regorafenib is a multi-target inhibitor and cephalosporins are antibiotics, but that doesn't mean there aren't possible interactions between them. Under normal circumstances, patients can take cephalosporins before taking regorafenib, but it is best to do so under the advice or guidance of a doctor to obtain personalized advice.

Although certain antibiotics may affect drug metabolism and clearance, affecting the effectiveness of regorafenib or increasing the risk of adverse reactions. For example, coadministration of strong CYP3A4 inducers with regorafenib reduces the plasma concentration of regorafenib, increases the plasma concentration of the active metabolite M-5, and may lead to a decrease in efficacy. If adverse events such as hepatotoxicity, infection, bleeding, gastrointestinal perforation or impotence occur during use, the doctor may reduce the dose or tell the patient to stop taking regorafenib for a period of time during treatment. The time for resumption of use also needs to be advised by the doctor.

RegofenibThe original drug has been launched in China and has entered the scope of Class B medical insurance. Reimbursement is limited to patients who meet the indications. SpecificationThe price of each box of 40mg*28 tablets is around RMB 5,000. The reimbursement ratio is different in different regions, and the price after reimbursement is different. The Turkish version of regorafeniboriginal drug specifications 40mg*28 tablets sold overseas is priced around RMB 6,400 per box (the price may fluctuate due to exchange rates). There are also generic regorafenib drugs produced in other countries, and their drug ingredients are basically the same as those of the original drug. The price of a box of 40mg*90 tablets produced by a Bangladesh pharmaceutical factory is around 2,900 yuan (the price may fluctuate due to exchange rates).