Where can I buy Entrectinib?

Entrectinib (Entrectinib) is a new generation of targeted therapy drugs that belongs to the class of multi-target tyrosine kinase inhibitors (TKI). It is designed to treat malignant tumors carrying specific gene mutations, mainly including neuroblastoma, ROS1 gene fusion-positive non-small cell lung cancer (NSCLC) and ALK gene fusion-positive NSCLC.

Entrectinib has been launched in China, but due to its short time on the market, it has not yet been included in the medical insurance catalog. Since it has just been launched, it is difficult to purchase domestically and the price is very high. For specific prices, please consult the hospital pharmacy at that time. There are original drugs and generic drugs abroad. The original drugs abroad are mainly European versions of original drugs. The price is about 45,000 yuan. The price is relatively high and may be unaffordable for ordinary families. Generic drugs are mainly Lao generic drugs, with prices ranging from 4,000 to 8,000yuan, which are much cheaper than original drugs, and the ingredients of original drugs and generic drugs are basically the same.

Entrectinib exerts its anti-tumor effect by inhibiting the activation of abnormal tyrosine kinase signaling pathways and interfering with the growth and spread of tumor cells. It is characterized by personalized treatment, which only acts on tumor cells carrying specific gene mutations, while having relatively little impact on normal cells.

For patients with neuroblastoma, entrectinib can inhibit the growth of tumor cells carryingNTRK gene fusion, providing a new treatment option. In addition, for patients with ROS1 gene fusion and ALK gene fusion-positive NSCLC patients, entrectinib can target the abnormal signals generated by these gene fusions to slow down or even stop the development of tumors.

Due to its multi-target effects and gene mutation correlation, entrectinib has shown significant anti-tumor activity in clinical trials. However, like other drugs, entrectinib may cause some side effects, including nausea, vomiting, and diarrhea. Therefore, when using entrectinib, doctors will formulate treatment plans and adjust dosage according to the patient's specific conditions.