What disease does Entrectinib treat?

Entrectinib (Entrectinib) is a multi-target tyrosine kinase inhibitor (TKI) drug, mainly used to treat some malignant tumors carrying specific gene mutations. It is mainly used for the following diseases:

1.Neuroblastoma (Neuroblastoma): Neuroblastoma is a common childhood malignant tumor that usually occurs near the adrenal glands. Some neuroblastoma patients carry NTRK gene fusions, which cause abnormal signaling and promote tumor cell growth. Entrectinib targets this gene mutation and inhibits the growth of tumor cells.

2.ROS1Gene fusion-positive non-small cell lung cancer (NSCLC): Non-small cell lung cancer is one of the most common types of lung cancer. Some NSCLC patients carry ROS1 gene fusions, which lead to abnormal signaling and promote the proliferation and survival of tumor cells. Entrectinib can inhibit the abnormal activity of ROS1 and thereby exhibit anti-tumor effects in these patients.

3.ALKgene fusion-positive non-small cell lung cancer (NSCLC): Similarly, some NSCLC patients carry ALKgene fusion, which can also lead to abnormal signaling and tumor cell proliferation. Entrectinib can inhibit the abnormal activity of ALK, thereby inhibiting tumors in such patients.

Entrectinib has been launched in China, but due to its short time on the market, it has not yet been included in the medical insurance catalog. Since it has just been launched, it is difficult to purchase domestically and the price is very high. For specific prices, please consult the hospital pharmacy at that time. There are original drugs and generic drugs abroad. The original drugs abroad are mainly European versions of original drugs. The price is about 45,000 yuan. The price is relatively high and may be unaffordable for ordinary families. Generic drugs are mainly Laotian generic drugs, with prices ranging from 4000~8000It is around 100 yuan, which is much cheaper than the original drug, and the ingredients of the original drug and the generic drug are basically the same.