Chinese instructions for Entrectinib

Enrectinib (trade name: Rozlytrek) is a targeted therapy drug that belongs to the class of multi-target tyrosine kinase inhibitors (TKI).

1. Indications: Entrectinib is suitable for patients with malignant tumors carrying specific gene mutations, mainly including:

1.Patients with neuroblastoma (Neuroblastoma) carrying NTRK gene fusion;

2.ROS1gene fusion-positive non-small cell lung cancer (NSCLC) patients;

3.ALKgene fusion-positive non-small cell lung cancer (NSCLC) patients.

2. Mechanism of action and pharmacology: Entrectinib is a multi-target tyrosine kinase inhibitor that can inhibit abnormal signaling pathways caused by gene mutations such as NTRK, ROS1 and ALK. By interfering with these signaling pathways, entrectinib can prevent cancer cell proliferation, division, and survival, thereby inhibiting tumor growth.

3. Dosage and usage: According to the recommendations of medical experts, entrectinib is usually used in oral form. Dosage and usage will vary according to the patient's specific situation and require individualized adjustments by the physician.

1.Patients are selected for treatment based on the presence of ROS1 rearrangements or NTRK gene fusions.

2.ROS1Recommended dose for positive non-small cell lung cancer: 600 mgorally, once a day.

3.NTRKRecommended dose for gene fusion-positive solid tumors-Adults: 600 mg orally once daily.

-Pediatric patients 12 years of age and older: Recommended dosage is based on body surface area (BSA) as follows

a.Body surface area greater than1.50m²: 600mg, once a day;

b.Body surface area1.11 to 1.50m²: 500mg, once a day;

c.Body surface area0.91 to 1.10m²: 400mg, once a day.

4. Side effects: The side effects of entrectinib may include gastrointestinal and systemic symptoms such as nausea, vomiting, diarrhea, fatigue, loss of appetite, etc. It may also cause neurological problems, abnormal liver function, etc.严重的副作用可能包括心律失常、间质性肺疾病等。 Patients should closely monitor side effects and communicate with their doctor while taking the medication.

5. Warnings and Precautions: When using entrectinib, patients should pay attention to the following:

1.Regularly check your physical condition and report any abnormalities;

2.Follow the doctor’s advice and medication instructions, and do not change the dosage on your own;

3.Share past medication use and health history with your doctor to avoid drug interactions or adverse reactions;

4.If serious side effects occur, seek medical attention immediately.

6. Contraindications: Entrectinib may interact with certain drugs, so it may not be suitable for use in some cases. Patients should use entrectinib under the guidance of their doctors.

7. Drug interactions: Entrectinib may interact with other drugs, including other drugs and supplements. Before using entrectinib, patients should inform their doctor about all medications they are taking to avoid adverse interactions.

8. Medication for special groups: For special groups such as pregnant women, lactating women and children, the use of entrectinib requires careful consideration and guidance from doctors. In these cases, the potential benefits of the drug need to be weighed against its risks.

9. Launch and price situation: Entrectinib has been launched in China, but due to its short time on the market, it has not yet been included in the medical insurance catalog. Since it has just been launched, it is difficult to purchase domestically and the price is very high. For specific prices, please consult the hospital pharmacy at that time. There are original drugs and generic drugs abroad. The original drugs abroad are mainly European versions of original drugs. The price is about 45,000 yuan. The price is relatively high and may be unaffordable for ordinary families. Generic drugs are mainly Lao generic drugs, with prices ranging from 4,000 to 8,000yuan, which are much cheaper than original drugs, and the ingredients of original drugs and generic drugs are basically the same.

To sum up, entrectinib is a targeted therapy drug used to treat patients with malignant tumors carrying specific gene mutations. During use, patients should strictly follow the doctor's advice, closely monitor side effects, and maintain close contact with the doctor. Treatment effects and courses will vary depending on individual differences and tumor types, and need to be carried out under the guidance of a doctor.

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