Synthetic route of Entrectinib

The synthetic route of Entrectinib (Entrectinib) involves multiple steps. Since this is a trade secret and patent-protected information, a detailed synthetic route cannot be provided. However, a general overview can be provided to understand the main steps and principles typically involved in synthesizing drugs.

The synthesis of entrectinib usually includes the following general steps:

1.Obtaining starting materials: The first step in the synthesis process is to obtain starting materials, which may be chemicals or existing intermediates. These starting materials require meticulous purification and separation to ensure high quality in the synthesis process.

2.Intermediate synthesis: Synthetic drugs usually involve the preparation of multiple intermediates. These intermediates may require multi-step reactions to build up the molecular structure step by step. The steps of chemical synthesis may involve substitution, condensation, deprotection and other reactions.

3.Coupling reaction: In the synthesis of entrectinib, a coupling reaction may be involved to connect different molecular parts. This reaction enables the step-by-step assembly of molecules.

4.Protecting groups and deprotection: During the synthesis process, sometimes it is necessary to introduce protecting groups to protect specific functional groups to prevent them from adverse reactions in other reactions. At the appropriate time, these protecting groups are removed.

5.Fine purification: After each synthesis step, the product needs to be finely purified and separated to remove impurities and by-products.

6.Final step: In the final stage of synthesis, the drug needs to undergo final processing and purification to obtain the final entrectinib product.

Entrectinib has been launched in China, but due to its short time on the market, it has not yet been included in the medical insurance catalog. Since it has just been launched, it is difficult to purchase domestically and the price is very high. For specific prices, please consult the hospital pharmacy at that time. There are original drugs and generic drugs abroad. The original drugs abroad are mainly European versions of original drugs, and the price is about 45,000. The price is about 100 yuan, which is relatively high and may be unaffordable for ordinary families. Generic drugs are mainly Lao generic drugs, with prices ranging from 4,000 to 8,000yuan, which are much cheaper than original drugs, and the ingredients of original drugs and generic drugs are basically the same.