How Entrectinib works

Entrectinib (Entrectinib) is a multi-target tyrosine kinase inhibitor (TKI) drug, mainly used to treat malignant tumors carrying specific gene mutations. Its main function is to inhibit the proliferation, division and survival of tumor cells by targeting abnormal signaling pathways caused by specific gene mutations, thereby achieving the following main effects:

1.Inhibit tumor growth: Entrectinib is a targeted therapy drug that targets tumors carrying gene mutations such as NTRK, ROS1 and ALK and inhibits the abnormal signaling pathways caused by these gene mutations. This helps inhibit the growth of tumor cells and slows tumor progression.

2.Tumor response and shrinkage: In some patients, entrectinib may cause tumor response and shrinkage. Particularly for patients with neuroblastoma who carry NTRK gene fusions, and non-small cell lung cancer patients who are positive for ROS1 and ALK gene fusions, the drug may lead to a reduction in tumor size, reduce symptoms and improve patients' quality of life.

3.Prolonged survival: Some patients may benefit from prolonged survival after taking entrectinib. The anti-tumor effect of the drug may lead to slowing of tumor progression, thereby prolonging patient survival.

4.Individualized treatment: The efficacy of entrectinib is closely related to whether the patient carries a specific gene mutation. This personalized treatment strategy helps improve the effectiveness of treatment and reduce unnecessary side effects.

It is important to note that each patient's situation is unique, and the efficacy of entrectinib will vary based on individual differences, tumor type, and genetic mutations. During the treatment process, doctors will monitor and evaluate the patient's specific situation and adjust the treatment plan according to changes in the tumor. If you or someone you know is considering or receiving treatment with entrectinib, it is recommended that you work closely with a medical professional to obtain the most accurate information and advice.

Entrectinib has been launched in China, but due to its short time on the market, it has not yet been included in the medical insurance catalog. Since it has just been launched, it is difficult to purchase domestically and the price is very high. For specific prices, please consult the hospital pharmacy at that time. There are original drugs and generic drugs abroad. The original drugs abroad are mainly European versions of original drugs. The price is about 45,000 yuan. The price is relatively high and may be unaffordable for ordinary families. Generic drugs are mainly Lao generic drugs, with prices ranging from 4,000 to 8,000yuan, which are much cheaper than original drugs, and the ingredients of original drugs and generic drugs are basically the same.