What is the difference between Entrectinib and Larotrectinib? Which one is better?

Entrectinib (Entrectinib) and larotrectinib (Larotrectinib) are both targeted therapy drugs used to treat specific gene fusion-positive tumors, but they have some differences, including indications, mechanisms of action, efficacy, etc. Which one is better depends on the patient's specific situation and tumor characteristics.

Entrectinib (Entrectinib):

1.Indications: Entrectinib is mainly suitable for patients carrying TRK, ROS1 and ALK gene fusions. These gene fusions will appear in some cancers, including lung cancer.

2.Mechanism of action: Entrectinib is a multi-target inhibitor that can inhibit the activity of multiple kinases, includingTRK, ROS1 and ALK. It inhibits the growth and spread of tumor cells by interfering with the signaling pathways of these kinases.

3.Efficacy: Entrectinib has shown significant efficacy in clinical trials, especially in tumors positive for TRK, ROS1 and ALK fusions. Clinical trial data indicate that entrectinib can induce tumor shrinkage or stabilization in patients with these gene fusion-positive tumors.

Larotrectinib (Larotrectinib):

1.Indications: Larotrectinib is suitable for patients carrying NTRK gene fusion. NTRKgene fusion is a genetic abnormality that occurs in a variety of cancers, including lung cancer.

2.Mechanism of action: Larotinib is a highly selective NTRKkinase inhibitor that can specifically inhibit the activity of NTRK gene fusion. By inhibiting the activity of this abnormal protein, it prevents the growth and spread of tumor cells.

3.Efficacy: The clinical trial data of larotrectinib also showed satisfactory efficacy. For patients who carry NTRK gene fusions, larotrectinib can significantly reduce or stabilize tumors.

Which drug is better depends on the patient's specific situation. Entrectinib may be a more suitable option if a patient's tumor harbors a TRK, ROS1, or ALK fusion. And if the tumor carries NTRK gene fusion, larotrectinib may be more suitable. In addition, factors such as the patient's condition, health status, other treatment options, and possible side effects should also be considered.

Final treatment decisions should be made under the guidance of a physician. Doctors will comprehensively consider the patient's situation, including genotype, tumor characteristics, health status, etc., to formulate the most appropriate treatment plan. Regardless of which medication is chosen, regular medical monitoring and follow-up are important to ensure patients receive the best possible results from their treatment.

Entrectinib has been launched in China, but due to its short time on the market, it has not yet been included in the medical insurance catalog. Since it has just been launched, it is difficult to purchase domestically and the price is very high. For specific prices, please consult the hospital pharmacy at that time. There are original drugs and generic drugs abroad. The original drugs abroad are mainly European versions of original drugs. The price is about 45,000 yuan. The price is relatively high and may be unaffordable for ordinary families. Generic drugs are mainly Lao generic drugs, with prices ranging from 4,000 to 8,000yuan, which are much cheaper than original drugs, and the ingredients of original drugs and generic drugs are basically the same.

Since larotrectinib was approved in China soon, it is difficult to purchase it in most pharmacies. Please consult your local pharmacy for details. Larotrectinib abroad is divided into original drugs and generic drugs. The original drugs are divided into multiple versions, mainly including the German version, the Hong Kong version and the American version. The German version is relatively expensive, with a specification of 100mg*56 tablets of about 70,000 yuan. The prices of the Hong Kong and American versions are between 25000 is about 2/3 cheaper than the German version of the original drug, and the ingredients are the same; generic drugs are mainly Bangladeshi generic drugs, the price is about at 2000~6000. Due to different manufacturers, the prices vary, and the ingredients of the original drugs are the same as those of generic drugs.