Will Pirfenidone be reimbursed by medical insurance?

Pirfenidone (Pirfenidone) is a pyridone derivative with anti-inflammatory, anti-fibrotic and antioxidant properties and is approved worldwide based on its ability to slow functional decline and disease progression. For the treatment of idiopathic pulmonary fibrosis, several pivotal clinical trials have shown that although its exact mechanism of action is unknown, pirfenidone has been found to significantly reduce the proportion of patients with a >10% decline in FVC during 52 weeks of follow-up and improve progression-free survival compared with placebo.

Idiopathic pulmonary fibrosis is a chronic, progressive, irreversible and fatal lung disease with an average life expectancy of 2-5 years after diagnosis. Its histopathological characteristics are subpleural fibrosis, subepithelial myofibroblast foci and microscopic honeycombing. Pirfenidone was safe and generally well tolerated, and the type and frequency of adverse events were consistent with the known safety profile of pirfenidone, including gastrointestinal events, which were the most common treatment-emergent adverse event. Adverse events reported during treatment were generally mild or moderate and rarely resulted in treatment discontinuation.

Pirfenidone has been approved for marketing in China under the trade name of Asri. It has entered the scope of Class B medical insurance and is limited to patients with idiopathic pulmonary fibrosis. The reimbursement ratio is different in different regions, and the price after reimbursement may be different. National The specifications produced by domestic pharmaceutical factories100mg*54 capsules per box are around 500 yuan. This medicine may be sold in domestic pharmacies or hospitals. There are also generic pirfenidone drugs produced in other countries overseas. For example, the price of a box of 200mg*30 tablets produced by an Indian pharmaceutical factory is around RMB 100 (the price may fluctuate due to the exchange rate). The ingredients of the generic drugs are basically the same as those of the original drug. For more drug information and specific prices, please consult Yaode Medical Consultant.