The Difference Between Finerenone and Spironolactone

Finerenone (Finerenone) and spironolactone are both drugs used to treat cardiovascular diseases, but they have some differences in their mechanisms of action, indications, side effects, etc. Here are the key differences between fenelidone and spironolactone:

1.Mechanism of action:

Finelidone is a ketosterol receptor antagonist that reduces the cardiovascular and renal effects of aldosterone by selectively antagonizing aldosterone receptors, thereby reducing cardiovascular burden, protecting the kidneys, and reducing the risk of heart failure recurrence and renal disease progression.

Spironolactone is a classic aldosterone receptor antagonist. It reduces the effect of aldosterone in the body by antagonizing aldosterone receptors. It is mainly used to treat hypertension and heart failure.

2.Indications:

Finelidone is indicated for the treatment of patients with chronic heart failure (CHF) to reduce the risk of recurrence of heart failure, and in patients with type 2 diabetes to reduce the risk of progression of kidney disease.

Sponolactone is mainly used to treat hypertension and heart failure, especially when patients are already receiving other treatments but still require additional heart failure treatment.

3.Side effects:

Fenelidone carries a lower risk of high blood potassium (hyperkalemia) than spironolactone. Because of its broad aldosterone receptor antagonism, spironolactone may cause hyperkalemia, especially when used with other drugs that may increase potassium.

Long-term use of spironolactone may cause side effects such as sex hormone imbalance. Especially in male patients, it may cause problems such as breast enlargement (breast hyperplasia). These problems are relatively less common with nonelidone.

4.Selection factors:

When choosing fenelidone or spironolactone, doctors will make judgments based on the patient's specific conditions, including disease type, severity, complications, etc. If the patient is at risk for hyperkalemia, or if sex hormone balance is a concern, fenelidone may be a better option.

In short, both fenelidone and spironolactone have unique characteristics in the treatment of cardiovascular diseases, and the choice should be based on the patient's specific situation and the doctor's recommendations. Before using any drug, you should fully communicate with your doctor to understand the drug's effects, side effects, and interactions with other drugs to ensure the most appropriate treatment plan.

Fenelidone is currently on the market in China and has been included in medical insurance. Patients can purchase it at domestic hospital pharmacies. For specific prices and prices after medical insurance reimbursement, please consult the local hospital pharmacy. Overseas, the main Japanese original drug is fenelidone, with a specification of 10mg*100 tablets of about more than 2,000 yuan, and it is the same as the domestic original drug.