Finerenone’s mechanism of action

Finerenone (Finerenone) is a ketosterol receptor antagonist mainly used to treat cardiovascular disease and diabetes-related kidney disease. Its mechanism of action mainly involves antagonism of aldosterone receptors, resulting in a series of important effects in the cardiovascular and renal systems.

Specifically, the mechanism of action of fenelinone is as follows:

1.Aldosterone receptor antagonism: Aldosterone is a hormone that regulates water and electrolyte balance in the body by binding to aldosterone receptors. However, in certain disease states, such as heart failure, hypertension, and diabetes, overactivity of aldosterone may lead to increased salt and water retention, inflammation, and fibrosis, thereby adversely affecting the cardiovascular and renal systems. Finelidone selectively antagonizes aldosterone receptors and blocks the binding of aldosterone to receptors, thereby reducing the activity of aldosterone, thereby reducing salt and water retention, and reducing the degree of inflammation and fibrosis.

2.Anti-inflammatory effect: Disease states such as hypertension and heart failure may trigger inflammatory reactions and aggravate cardiovascular and renal damage. The antagonism of fenelinone can reduce the production of inflammatory factors and reduce the inflammatory response, thus exerting a protective effect on the cardiovascular and renal systems.

3.Reducing fibrosis: In heart failure, hypertension and kidney disease, tissue fibrosis (the proliferation of connective tissue) may lead to damage to organ structure and function. Fennelidone can reduce the degree of fibrosis and help maintain normal tissue structure and function.

Fenelidone is currently on the market in China and has been included in medical insurance. Patients can purchase it at domestic hospital pharmacies. For specific prices and prices after medical insurance reimbursement, please consult the local hospital pharmacy. Overseas, the main Japanese original drug is fenelidone, with a specification of 10mg*100 tablets of about more than 2,000 yuan, and it is the same as the domestic original drug.