How many years does it take for resistance to Fulvestrant to develop?

Fulvestrant (Fulvestrant) is an important endocrine therapy drug commonly used in the treatment of hormone receptor-positive advanced breast cancer. However, drug resistance is a complex problem, and its development time varies depending on factors such as individual differences, tumor characteristics, and treatment regimens, making it difficult to simply define a fixed resistance time.

Drug resistance is a major challenge in cancer treatment. In the early stages of treatment with fulvestrant, patients often show a strong response to the drug, with a reduction in tumor burden and symptomatic relief. However, as treatment progresses, some tumor cells may gradually adapt to the effects of the drug and become resistant. This may cause the medication to gradually lose effectiveness and the disease to progress again.

Generally, the development of drug resistance is unpredictable. Some patients may remain sensitive to the drug for years after treatment with fulvestrant, while others may develop resistance within a short period of time. This depends on many factors, including the molecular characteristics of the tumor, mutation status, tumor microenvironment, and individual genetic background.

To slow the development of drug resistance, doctors often closely monitor patients' condition and response to treatment. In the presence of signs of resistance, treatment modifications may be considered, such as combining other drugs, changing doses, or using different treatment strategies.

Fulvestrant injection has been launched in China and has been included in medical insurance. Patients can buy it domestically. The price of domestically imported original drugs is around 5,000 to 6,000 yuan, while domestic drugs are slightly cheaper. For specific prices, please consult the local hospital pharmacy or the medical insurance bureau. There is only Fulvestrant's original drug abroad. The cheaper original drugs are mainly the Turkish original drug and the Indian version of the original drug. The price is around 1,000~2,000 yuan, and the ingredients and efficacy of the original drugs at home and abroad are the same.