How much does a box of Pemigatinib cost?

The U.S. Food and Drug Administration (FDA)approved pemigatinib (Pemigatinib) for the treatment of unresectable locally advanced or metastatic cholangiocarcinoma in adult patients who have previously received fibroblast growth factor receptor 2 (FGFR2) gene fusion or other rearrangement therapy. Studies have shown that up to 45% of patients with intrahepatic cholangiocarcinoma have gene rearrangements that lead to oncogenic fibroblast growth factor 2 (FGFR2) fusion proteins.

The FDA-approved indication for pemetinib was granted accelerated approval based on overall response rate and duration of response in premarket clinical trials in which participants received pemetinib once daily for 14 consecutive days. , and then stop taking the drug for 7 days, in a 21-day cycle, until the disease progresses or the patient experiences unreasonable levels of side effects. The overall response rate was 36%, of which 2.8% of participants had complete remission and 33% of participants had partial remission.

The original drug of pemetinib has been launched in China. Due to its short time on the market, it has not yet entered the scope of medical insurance. The price of each box of 4.5mg*14 tablets may be around 30,000 yuan, which is expensive. The price of the original pemetinib drug, 13.5mg*14 tablets, per box sold overseas may be around RMB 70,000 (the price may fluctuate due to exchange rates). There are also generic pemetinib drugs produced in other countries overseas. For example, the price of a box of 4.5mg*21 tablets produced by a Laos pharmaceutical factory may be around 3,000 yuan (the price may fluctuate due to the exchange rate). The price is relatively cheap. The pharmaceutical ingredients of the generic drugs are basically the same as those of the original drugs at home and abroad.