Gilteritinib side effects

Gilteritinib (Gilteritinib) is a targeted therapy drug used to treat acute myeloid leukemia (Acute Myeloid FLT3 gene mutation subtypes in patients with Leukemia, AML). Although giritinib has shown significant efficacy in the treatment of AML, it may also cause some side effects. This article will detail the side effects of giritinib so that patients and physicians can better understand and manage these adverse effects.

General side effects:

1. Nausea and vomiting: Nausea and vomiting are common side effects during geritinib treatment. These symptoms may affect the patient's appetite and quality of life. Doctors often recommend that patients take steps to reduce these symptoms, such as eating in portions and using anti-nausea medications.

2. Diarrhea: Diarrhea is also one of the common side effects during geritinib treatment. Patients may experience frequent bowel movements, which may lead to water loss and electrolyte imbalance. It is important to maintain adequate fluid intake and discuss with your doctor any medications you may need to control diarrhea.

3. Fatigue: Some patients report experiencing fatigue while taking giritinib. This fatigue may affect a patient's daily activities, so rest and good sleep are essential to manage this side effect.

4. Skin problems: Giritinib may cause some skin problems, such as rash and itching. These symptoms are usually mild, but in some cases medical intervention may be required. Patients should regularly inform their doctor about skin symptoms.

5. Myelosuppression: Giritinib may suppress normal bone marrow function, resulting in a decrease in white blood cell, red blood cell, and platelet counts. This can lead to anemia, susceptibility to infection, and bleeding tendencies. Doctors usually monitor blood counts and take necessary steps to manage these problems.

Cardiovascular side effects:

1. QT prolongation: Giritinib may cause prolongation of the QT interval on the electrocardiogram, which is a risk factor for irregular heartbeats. Therefore, doctors often monitor EKGs regularly during treatment to check for this problem. Patients should tell their doctor about any symptoms of heart or irregular heartbeat problems.

Abnormal liver function:

1. Elevated liver enzymes: Giritinib may cause elevated liver enzyme levels, which are indicators of abnormal liver function. Doctors usually check liver function regularly and take steps to manage this side effect if necessary.

Eye side effects:

1. Vision problems: Some patients may report vision problems, such as blurred or dry eyes, while taking giritinib. If these problems occur, patients should inform their doctor promptly for advice.

Other side effects:

1. Gastrointestinal bleeding: Giritinib may increase the risk of gastrointestinal bleeding. Patients should pay close attention to any symptoms of gastrointestinal bleeding, such as melena or vomiting blood, so that they can seek prompt medical attention.

2. Cataracts: In some patients, giritinib may cause the development of cataracts. Therefore, patients should receive regular eye exams during treatment.

It should be noted that the above-mentioned side effects may not occur in every patient taking giritinib, and the severity of side effects varies between individuals. During treatment, patients should be regularly monitored and evaluated by their physician to ensure that side effects are managed promptly. In addition, patients should actively cooperate with their doctors to report any new or worsening side effects so that appropriate measures can be taken promptly. In short, giritinib is a drug that has the potential to improve the prognosis of AML patients, but it may also cause some side effects, so patients should use it under the guidance of a doctor and pay close attention to their physical condition.

Giritinib is currently on the market in China, but it is not included in medical insurance. If patients need it, they can go to the hospital to buy it at their own expense, but the price is very high, about 35,000It’s about RMB 1,000. Please consult the local hospital pharmacy for specific prices. Foreign original drugs of gilitinib are even more expensive. For example, the price of the Hong Kong version of the original drug is around 90,000 yuan, and the European version of the original drug is as high as more than 200,000 yuan, which is simply unaffordable for ordinary patients. There are already foreign generic drugs of Giritinib on the market, mainly Laos generic drugs. The price is about four to five thousand yuan, which is relatively cheap. In terms of drug ingredients, the ingredients of domestic and foreign original gilitinib drugs are basically the same as those of generic drugs.