Effects of taking Pazopanib for 2 months

Pazopanib is approved for the second-line treatment of renal cell carcinoma and non-adipocyte soft tissue sarcoma. However, its cardiovascular side effects limit its clinical efficacy. Pazopaniband other vascular endothelial growth factor receptor tyrosine kinase inhibitors are associated with the development of hypertension, QT interval prolongation and other cardiovascular events.

In vitro studies have shown that pazopanib is metabolized by CYP3A4, with a small amount of CYP1A2 and CYP2C8, and is mainly excreted through feces. Renal excretion accounts for <4% of the administered dose. After the recommended dose of 800 mg is administered, the average half-life of pazopanib is 31 hours. The effects of taking pazopanib after 2 months will vary from person to person, and patients may observe some improvement during the early stages of taking pazopanib. Some of the common effects include reducing tumor size, relieving pain and discomfort, reducing fatigue, and more. However, the extent and speed of these effects will vary depending on individual circumstances.

PazopanibThe original drug has been launched in China and has entered the scope of Class B medical insurance, but reimbursement is limited to patients who meet the indications. The price of each box may be around 3,000 yuan. The price of pazopanib original drug specifications200mg*30 tablets marketed overseas may be around 1,000 RMB per box (the price may fluctuate due to exchange rates). There are also pazopanib generic drugs produced in other countries. The price of 200mg*30 tablets produced by Bangladesh pharmaceutical factory may be around 500 yuan per box (the price may fluctuate due to the exchange rate), which is cheaper. The pharmaceutical ingredients of generic drugs are basically the same as those of domestic and foreign original drugs.