Is ldelalisib a targeted drug?

Idelalisib (Idelalisib) is a targeted drug. Targeted drugs are a class of drugs designed to interfere with specific molecules or signaling pathways to inhibit the growth and spread of cancer or other diseases. The targeting nature of idelalix is u200bu200bmainly reflected in its action on the phospholipase Cδ (PI3Kδ) signaling pathway.

The main function of idelalix is to inhibit the activity of phospholipaseCδ (PI3Kδ). PI3Kδ is a phospholipase located on the cell membrane. It plays a key role in regulating cell growth, proliferation and survival. In particular, PI3Kδ plays an important role in lymphocytes, which are closely related to the immune system and the development of leukemia.

The targeting nature of idelalix is reflected in its selective inhibition ofPI3Kδ. This selectivity allows it to primarily affect disease-related abnormal cells and relatively less to normal cells, thereby reducing adverse reactions caused by the drug.

Idelalistat is approved to treat chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL), two B cell-related diseases. Its targeted effects help slow the progression of these diseases and improve patients' survival rates and quality of life.

The targeting nature of idelalisib makes it more specific and less systemic toxic than traditional chemotherapy drugs. This means patients can better tolerate the treatment, reducing the discomfort and complications that often accompany chemotherapy.

However, like all drugs, idelalix may be associated with some adverse reactions, including diarrhea, fever, infection, fatigue, etc. Therefore, patients need to receive treatment under the supervision of a doctor and undergo regular examinations to monitor its efficacy and adverse reactions.

Idelalis is not currently available in the country, so it is not included in medical insurance. Patients cannot purchase it domestically and need to purchase it through overseas channels. There are only original drugs of iderallis available abroad, mainly from the United States, and the price is as high as about 38,000 yuan.