Chinese instructions for ldelalisib

1. Indications:

Idelalisi is a targeted drug used to treat two specific types of leukemia and lymphoma:

Chronic lymphocytic leukemia (CLL): CLL is a type of chronic lymphocytic leukemia that usually affects B lymphocytes. Idelalistat is indicated for the treatment of adult patients, particularly those who are refractory to or intolerant to other treatments.

Small lymphocytic lymphoma (SLL): SLL is a B lymphocyte-associated lymphoma similar to CLL and usually occurs in the lymph nodes. Idelalisi is also suitable for adult patients with SLL, especially those who have had poor response to or intolerance to other treatments.

2. Mechanism of action:

The main mechanism of action of idelalix is to inhibit phospholipaseCδ (PI3Kδ). PI3Kδ is a signaling pathway protein that plays a key role in B cells and regulates cell survival, proliferation and migration. By selectively inhibiting PI3Kδ, idelalix can specifically affect the proliferation and survival of leukemia and lymphoma cells, thereby slowing disease progression.

3. Pharmacology:

Idelalistat is an oral medication that is usually available in tablet form. After the drug is absorbed in the body, it quickly enters the blood circulation and is then distributed into cells, especiallyB cells. It has a short half-life in the body and needs to be taken daily.

4. Dosage and usage:

Patients should use idelalix exactly as prescribed and recommended by their doctor. Typically, the recommended dose for adult patients is 150 mg orally twice daily. Medication should be taken after meals to reduce the risk of gastrointestinal upset. Medication regimens may vary depending on a patient's specific condition, so doctor's recommendations must be followed closely.

5. Side effects:

Using idelalix may be associated with the following common side effects:

1.Diarrhea: Diarrhea is one of the most common side effects and may affect the patient's quality of life. During treatment, patients should maintain adequate fluid intake to prevent dehydration.

2.Fever: Some patients may experience fever, which usually requires medical supervision.

3.Infection: Because idelalix affects the function of the immune system, patients are more susceptible to infections. Patients should receive regular medical examinations and blood tests to monitor the risk of infection.

4.Fatigue: Fatigue and weakness may occur, affecting the patient's daily activities.

5.Difficulty breathing: Some patients may experience difficulty breathing while taking this medication. If such symptoms occur, you should contact your doctor immediately.

The severity of these side effects varies among patients. Patients should pay close attention to their physical condition during medication and report any discomfort to their doctor in a timely manner.

6. Warnings and Precautions:

1.Using idelalix may affect the immune system and increase the risk of infection. Patients should avoid contact with infected people and undergo regular medical examinations to monitor for signs of infection.

2.Patients may experience severe diarrhea while taking this medication. If diarrhea is severe or lasts for a long time, contact your doctor immediately.

3.Idelalistat may cause abnormal liver function, so patients need to undergo regular liver function monitoring.

4.During medication, patients should undergo regular blood tests to monitor changes in white blood cells, platelets and other blood parameters.

7. Contraindications:

Idelarix has some contraindications, including:

This medication should not be used by patients who are allergic to idelalix or any of its components.

Pregnant and nursing women should avoid the use of idelalix because it may cause adverse effects to the fetus or infant.

8. Drug interactions:

While taking idelalix, patients should tell their doctors about other medications they are taking, including prescription drugs, over-the-counter drugs, and supplements. Some drugs may interact with idelalix, increasing the risk of adverse reactions or making the drug less effective.

9. Drugs for special groups:

For special groups, such as elderly patients or patients with impaired liver and kidney function, it may be necessary to adjust the dose or take other measures to ensure the safety and effectiveness of the medication.

10. Listing and price situation:

Idelalis is not currently on the market in China, so it is not included in medical insurance. Patients cannot purchase it domestically and need to purchase it through overseas channels. There are only original drugs of iderallis available abroad, mainly from the United States, and the price is as high as about 38,000 yuan.