Contraindications when taking the targeted drug Imatinib

Imatinib (Imatinib) is an important targeted therapy drug used to treat a variety of leukemias and tumors, including chronic myelogenous leukemia (CML pan>), acute lymphoblastic leukemia (ALL), and cortical renal cancer (GIST). Although imatinib has achieved remarkable therapeutic effects in many patients, there are still some contraindications and potential risks. The following is detailed information on contraindications to imatinib:

1. Allergic reaction:

Imatinib may cause an allergic reaction. Patients should avoid using this medication if they are allergic to imatinib or any of its components. Symptoms of an allergic reaction include itchy skin, hives, shortness of breath, facial swelling, and throat tightness. If patients experience any allergic symptoms, they should seek medical attention immediately.

2. Abnormal liver function:

Imatinib may have adverse effects on the liver and cause abnormal liver function. Therefore, patients should undergo regular liver function monitoring while taking imatinib. If you develop jaundice, abdominal discomfort, loss of appetite, fatigue, or other liver-related symptoms, notify your doctor as soon as possible.

3. Cardiovascular problems:

Imatinib use may be associated with cardiovascular problems (such as arrhythmia, myocardial infarction, heart failure, etc.). Before patients start treatment with imatinib, doctors usually perform an electrocardiogram and a heart health assessment. If a patient has a known cardiovascular problem, doctors may need to carefully weigh the potential risks and benefits before deciding whether to use imatinib.

4. High blood pressure:

Imatinib can cause high blood pressure; therefore, patients should have their blood pressure monitored regularly during treatment. If the patient already has a history of high blood pressure or cardiovascular disease, doctors may need to monitor them more closely.

5. Pregnancy and lactation:

Imatinib may cause harm to the fetus and should be avoided in women who are pregnant or planning to become pregnant. During treatment, women should use reliable contraceptive measures to prevent pregnancy. At the same time, it is unknown whether imatinib is excreted in breast milk, so breastfeeding women should also consult their doctors to weigh the benefits of treatment against potential risks.

6. Abnormal kidney function:

Imatinib may have adverse effects on the kidneys, leading to abnormal renal function. Patients should receive regular renal function monitoring during treatment to ensure normal kidney function. If you develop urine changes, edema, or other kidney-related symptoms, you should notify your doctor promptly.

7. Drug interactions:

Imatinib may interact with other drugs, affecting their metabolism and effectiveness. Therefore, before starting treatment with imatinib, patients should inform their doctor about all medications they are taking, including prescription drugs, over-the-counter drugs, and supplements.

In summary, imatinib is a powerful treatment, but its use requires careful consideration of potential contraindications and risks. Patients should discuss their medical history, drug allergies and possible contraindications in detail with their doctor before starting treatment to ensure safe and effective treatment. Doctors will develop the most appropriate treatment plan based on the patient's situation and needs, and regularly monitor the progress of treatment and potential adverse reactions. Prompt medical consultation and following your doctor's recommendations are critical to using imatinib safely.

Imatinib was launched in China as early as 2003. The domestic medical insurance price is about 700 yuan, and the specification is 100mg*60. Due to the large differences in medical insurance in different places, please consult the local pharmacy or medical insurance bureau for specific prices. Foreign medicines are divided into original drugs and generic drugs. Original drugs are mainly Turkish original drugs, and the price is relatively high, about 3300 yuan; generic drugs are mainly Indian generic drugs, and the Indian generic drugs specifications 100mg*120 are priced at around a few hundred yuan, which is much cheaper than domestic ones. The ingredients of foreign original drugs and generic drugs are basically the same as those of domestic imatinib.