Usage and dosage of Obeticholic acid

Before starting obeticholic acid (Obeticholic acid), doctors should determine whether the patient has decompensated cirrhosis (e.g.Child-Pugh Grade B or C), whether there has been a previous decompensatory event, or whether you have compensated cirrhosis with portal hypertension (e.g., ascites, gastroesophageal varices, sustained thrombocytopenia), as obeticholic acid is contraindicated in these patients.

Obeticholic acid is a prescription drug, and its use needs to be under the guidance of a doctor. For patients with primary cholangitis (PBC) without cirrhosis or compensated cirrhosis, who have no evidence of portal hypertension, have not achieved an adequate biochemical response to appropriate doses of ursodeoxycholic acid for at least 1 year, or are intolerant to ursodeoxycholic acid In affected patients, the recommended dose is 5 mg orally once daily during the first 3 months of initiating obeticholic acid, increasing to a maximum dose of 10 mg once daily after the first 3 months in patients who have insufficient reductions in ALP and/or total bilirubin and in patients who tolerate obeticholic acid.

The original drug of obeticholic acid has not yet been marketed in the country, so it has not been included in medical insurance. The original obeticholic acid drug marketed overseas is expensive, with each box costing around tens of thousands of yuan. The price is also affected by exchange rates and is unstable. It is understood that obeticholic acid has been produced as a generic drug and its ingredients are basically the same as those of the original drug. For example, the price of 5mg*30 tablets produced by a Bangladesh pharmaceutical factory is around RMB 1,000 per box (the price may fluctuate due to the exchange rate), and the price is cheap. For more drug information and specific prices, please consult a medical consultant.