Zhengda Tianqing’s Obeticholic acid tablets

It is understood that the domestic drug Obeticholic acid (Obeticholic acid) produced by Zhengda Tianqing has not yet been launched, and the original drug of obeticholic acid has not yet been launched in China. Obeticholic acid can be used alone Used with or in combination with ursodeoxycholic acid (UDCA) for the treatment of primary biliary cholangitis (PBC) in patients who do not have liver problems (such as cirrhosis) or who have compensated cirrhosis and do not have portal hypertension (increased pressure in the portal vein) who are receiving UDCA but are not responding well. It is available only with a doctor's prescription.

Obeticholic acidis a modified synthetic bile acid that acts as a farnesoidX-activated receptor (FXR) agonist. Farnesoid X-activated receptors are mainly expressed in human intestinal cells and hepatocytes. Natural bile acids are often ligands of FXRs. In intestinal epithelial cells, FXRs regulate bile acid synthesis and release of fibroblast growth factors, particularly FGF-19, into the portal circulation. Obeticholic acid is available as 5 or 10 mg oral tablets in patients with PBC who have an inadequate response to or intolerance to UDCA.

Since the original drug of obeticholic acid has not yet been marketed in the country, it cannot be included in medical insurance. The original obeticholic acid drug marketed overseas is expensive, with each box costing around tens of thousands of yuan. The price is also affected by exchange rates and is unstable. It is understood that obeticholic acid has been produced as a generic drug and its ingredients are basically the same as those of the original drug. For example, the price of 5mg*30 tablets produced by a Bangladesh pharmaceutical factory is around RMB 1,000 per box (the price may fluctuate due to the exchange rate), and the price is cheap. For more drug information and specific prices, please consult a medical consultant.