Obeticholic acid: Which one is better, Indian or Bangladeshi?

Obeticholic acid (Obeticholic acid) produced in India and Bangladesh belongs to the category of generic drugs. The original manufacturer of obeticholic acid is Intercept Pharmaceuticals Inc. The pharmaceutical ingredients of generic drugs are basically the same as those of the original drug, and there may be some differences in production specifications, prices, etc.

Obeticholic acid is an FXR agonist that is effective in combination with UDCA for the treatment of adults with primary biliary cholangitis (PBC) who have responded poorly to ursodeoxycholic acid(UDCA) or who cannot tolerate UDCA as monotherapy. Obeticholic acid is absorbed in the gastrointestinal tract. When the oral dose is 5-10 mg, the Cmax of obeticholic acid appears about 1.5 hours later, ranging from 28.8-53.7ng/mL. The median Tmax for both cholic acid conjugates was approximately 10 hours. One report showed that Tmax was 4.5 h for both 5 mg and 10 mg doses, and the AUC range for 5 mg to 10 mg doses was 236.6-568.1 ng/h/ml.

The original drug of obeticholic acid has not yet been marketed in the country, so it has not been included in medical insurance. The original obeticholic acid drug marketed overseas is expensive, with each box costing around tens of thousands of yuan. The price is also affected by exchange rates and is unstable. The price of obeticholic generic drug specifications5mg*30 tablets produced by Bangladesh Beacon is more than 1,000 yuan per box. The price of 5mg*30 tablets produced by Indian pharmaceutical factory is about several hundred yuan (the price may fluctuate due to the exchange rate). For more drug information and specific prices, please consult Yaode Medical Consultant.