What should I do if I become resistant to Orlistat?

Orlistat (Orlistat works by binding to fat and expelling it from the body. When patients take Orlistat capsules, approximately one-third of the fat in the meal cannot be digested, effectively reducing the patient's fat intake and thus the number of calories the body must use. Patients usually need to change their diet so that they do not consume more fat than Orlistat can handle. During treatment, you should eat an average of 30% of your calories from fat.

For many people, this is a lower-fat diet than what they normally eat, which means lower calorie intake, which will naturally aid weight loss. If a patient shows signs of resistance, doctors may consider adjusting the dose or dosing schedule of orlistat. This can help patients regain their ability to respond to medications. Lifestyle changes are critical to the success of any weight loss program, including a low-calorie healthy eating plan, physical activity, and behavioral therapy. Any drug treatment for overweight and obesity should be used in conjunction with lifestyle changes rather than as a single therapy. Everyone’s constitution is different and their resistance to drugs is also different. If you feel unwell, please inform your doctor in time.

The original drug of Orlistat has been marketed in China, but it has not yet entered the scope of medical insurance. There are also domestically produced drugs developed by other pharmaceutical companies on the market. The price of each box may be around tens of RMB, which is cheap. The price of the Indian version of Orlistat listed overseas is 120mg*84 capsules per box, which may be around a few hundred yuan (the price may fluctuate due to exchange rates). The ingredients of the two drugs are basically the same, but the manufacturers are different, and patients can choose by themselves.