Will I relapse after taking ozanimod?

OnDAYBREAK In the extension study, the safety profile was consistent with previous study results. No new safety signals emerged from long-term use of ozanimod during this reporting period. Ozamod treatment showed a low annual recurrence rate of 0.103. Rate (ARR),At 75% and 71% of participants were relapse-free at 36 and 48 months, and confirmed disability progression was observed in 13.9% and 11.4% of participants in the trial at 3 and 6 months, respectively.

Ozamod binds to S1P receptor subtype 1 (S1P1) and receptor subtype 5 (S1P5) through high affinityS1P is a signaling lipid The receptor is expressed in multiple organs and systems and helps control many cellular processes, including inflammation, vascular permeability, cancer growth, and adaptive immunity (also known as acquired immunity) by regulating T cell trafficking and innate immunity, blocking the ability of lymphocytes to escape from lymph nodes. Three months after the start of treatment, the average lymphocyte count dropped to approximately 45% of baseline and remained low with continued treatment. After discontinuation of medication, peripheral lymphocyte counts usually return to normal within 30 days.

The original drug Ozamod has been launched in China, but it has been on the market for a short time and has not been included in the medical insurance. The specific price is not yet clear, and domestic purchase channels are relatively difficult. The price of Ozamod original drug specifications0.92*28 capsules per box listed overseas may be around 19,000 yuan (the price may fluctuate due to the exchange rate), which is expensive. There is currently no generic version of Ozamod produced and launched. For more drug information and specific prices, please consult the medical consultant of Yaode.