Which country is Delamanid from?

Delamanid was discovered by Otsuka Pharmaceutical and first received regulatory approval in Japan and the European Union in 2014 for the treatment of adult patients with multidrug-resistant tuberculosis as part of a combination treatment regimen. In 2014, WHO issued interim policy guidance on the use of delamanid in the treatment of multidrug-resistant tuberculosis. In 2015, delamanid was included in the WHO Model List of Essential Medicines.

Delamanid is a dihydronitroimidazole derivative that acts by inhibiting the synthesis of mycobacterial cell wall components methoxymycolic acid and ketomycolic acid. Delamanid is a prodrug that is activated by denitroflavin-dependent nitroreductase (Rv3547), and the active intermediate metabolite formed between delamanid and denitroimidazole derivatives is thought to play an important role in inhibiting mycolic acid production. In in vitro studies, delamanid showed enhanced antibacterial activity against drug-susceptible and drug-resistant strains of Mycobacterium tuberculosis. Minimum inhibitory concentrations were observed in the very low range of 0.006-0.024 μg/ml. Post-antibiotic effects on intracellular organisms after pulse therapy have been demonstrated and are comparable to rifampicin. Delamanid has no mutagenicity in bacterial reverse mutation tests and has demonstrated high efficacy in rapidly eradicating Mycobacterium tuberculosis in experimental mouse models.

The original drug Delamani has been launched in China and is included in the scope of Class B medical insurance. Reimbursement is limited to patients with multi-drug-resistant tuberculosis. Specifications The price of each box of 50mg*60 tablets may be around RMB 6,000. The price of the Russian version of the original drug Dramani, 50mg*48 tablets, sold overseas may be around RMB 1,000-2,000 per box (the price may fluctuate due to the exchange rate). There is currently no generic version of Dramani available on the market. For more drug information and specific prices, please consult Yaode’s medical consultant.