Effect of Olaparib on triple-negative breast cancer

Triple-negative breast cancer(TNBC) cells are sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors used as radiosensitizers. Whether combining PARP inhibitors and radiation therapy in patients with TNBC will enhance the bioavailability of radiation therapy and improve locoregional control is unknown.

Olaparib was administered orally in tablet form in ascending doses (50 mg, 100 mg, 150 mg or 200 mg twice daily). Lynparib treatment was started 1 week before and at the same time as radiotherapy. After breast-conserving surgery, the entire breast received a total dose of 50.4-gy, and for patients 60 years old, the tumor bed simultaneously received a combined enhancement of 63-gy. A total dose of 50-Gy is delivered to the chest wall (post-mastectomy) or to the entire breast (unresectable tumors) after radical mastectomy or for unresectable tumors after neoadjuvant chemotherapy. In the case of node-positive disease, regional lymph node stations can be treated with a total dose of 50.0-50.4-gy.

Among the 24 patients included in the trial, no dose-limiting toxic effects were observed, and olaparib was titrated to 200 mg twice daily without reaching the maximum tolerated dose. Results from a phase 1 dose-escalation trial indicate that olaparib-suppressed PARP is well tolerated in patients with early-stage, high-risk TNBC when used concurrently with radiotherapy and should continue to be evaluated in further clinical trials.

Lynparza The original drug has been launched in China and has entered the scope of Class B medical insurance, but it is only available to patients who meet the indications. The price of each box of 150mg*56 tablets may be around RMB 6,000. There are price differences for drugs of different specifications. There are also Olaparibgeneric drugs produced overseas. The specifications produced by Bangladesh pharmaceutical factories150mg*120 tablets per box may cost around RMB 4,000 (the price may fluctuate due to the exchange rate). Its drug ingredients are basically the same as those of the Olaparib original drug. For more drug information and specific prices, please consult Yaode Medical Consultant.