Is it useful to take 300mg of Olaparib a day?

Following a single dose of olaparib 25 mg to 45 0 mg (0.08 to 1.5 times the recommended dose), the area under the curve (AUC) of olaparib increased approximately proportionally, and the increase in maximum concentration (Cmax) was slightly less than the proportional increase over the same dose range. Lynparib exhibits time-dependent pharmacokinetics, with a mean AUC accumulation ratio of 1.8 observed at steady state following twice daily dosing of 300 mg.

Single doseAfter 300 mg of olaparib, the mean (CV%) olaparib Cmax was 5.4 μg/mL (32%) and AUC was 39.2 μg*h/mL (44%). Following twice daily 300 mg doses, the mean steady-state Cmax and AUC of olaparib were 7.6 μg/mL (35%) and 49.2 μg*h/mL (44%), respectively. After oral administration of olaparib, the median time to peak plasma concentration is 1.5 hours. Coadministration of a high-fat, high-calorie meal (800-1000 kcal, 50% of calories composed of fat) with olaparib slowed the rate of absorption (tmax was delayed by 2.5 hours) but did not significantly change the extent of olaparib absorption (mean AUC increased by approximately 8%).

Lynparza The original drug has been launched in China and has entered the scope of Class B medical insurance, but it is only available to patients who meet the indications. The price of each box of 150mg*56 tablets may be around RMB 6,000. There are price differences for drugs of different specifications. There are also Olaparibgeneric drugs produced overseas. The specifications produced by Bangladesh pharmaceutical factories150mg*120 tablets per box may cost around RMB 4,000 (the price may fluctuate due to the exchange rate). Its drug ingredients are basically the same as those of the Olaparib original drug. For more drug information and specific prices, please consult Yaode Medical Consultant.