What are the side effects of Obinutuzumab?

Common adverse reactions of Obinutuzumab include infusion-related reactions, fever, cough, musculoskeletal disorders, neutropenia, lymphopenia, leukopenia, thrombocytopenia, hypocalcemia, hyperkalemia, hyponatremia, elevated transaminase (i.e. AST, ALT) concentrations, elevated Scr, hypoalbuminemia, elevated serum alkaline phosphatase concentrations, and hypokalemia.

The most severe toxicities observed with otuzumab were hepatitis B virus (HBV) reactivation and progressive multifocal leukoencephalopathy (PML). All anti-CD20 antibodies can cause HBV reactivation and can lead to liver failure, fulminant hepatitis, and death. PML is the result of JC virus infection and can also be fatal. Other common but less serious adverse reactions include infusion reactions (pretreat with glucocorticoids, acetaminophen, and antihistamines to prevent this reaction), neutropenia, thrombocytopenia, and tumor lysis syndrome (TLS) (pretreat patients with antihyperuricemia and hydration, especially those with high lymphocyte counts and/or high tumor burden). It is also recommended not to receive live virus vaccines before or during treatment with otuzumab.

The original drug of Otuzumab has been launched in China and has entered the scope of medical insurance, but it is only reimbursed for patients who meet the indications. Specifications The price of 1000mg (40ml)*1 bottle may be around 9,000 yuan, which is a strictly controlled drug. The price of the Turkish version of Otuzumab Specifications1000mg/40ml per box listed overseas may be around RMB 10,000 (the price may fluctuate due to the exchange rate). The ingredients of the original drugs sold domestically and abroad are basically the same. There is currently no generic version of Otuzumab produced and launched. For more drug information and specific prices, please consult the medical consultant of Yaode.