How to take Nilotinib

The patient took Nilotinib on an empty stomach twice a day with an interval of about 12 hours. You should not eat anything for at least 2 hours before taking this medicine and for at least 1 hour after taking this medicine. Patients are advised to swallow the capsule whole with water. For patients who are unable to swallow capsules, the contents of each capsule may be dispersed in 1 teaspoon of applesauce (apple puree). The mixture should be taken immediately (within 15 minutes) and should not be stored for future use. If clinically indicated, nilotinib can be used in combination with hematopoietic growth factors such as erythropoietin or G-CSF; or with hydroxyurea or anagrelide.

（1) Adult patients with newly diagnosed Ph+CML-CP: The recommended dose of nilotinib is 300 mg orally twice daily.

(2) Adult patients who are intolerant or intolerant to Ph+CML-CP and CML-AP: The recommended dose of nilotinib is 400 mg orally twice daily.

(3) Pediatric patients with newly diagnosed Ph+CML-CP or drug resistance or intolerance to Ph+CML-CP and CML-AP: The recommended dose of nilotinib for pediatric patients is 230 mg/m2 orally twice daily, rounded to the nearest 50 mg dose (maximum single dose is 400 mg). If necessary, obtain the desired dose by combining nilotinib capsules of different strengths. Treatment was continued as long as clinical benefit was observed or until unacceptable toxicity occurred.

Dose based on body surface area (BSA) ≤ 0.32 m2: 50 mg per dose; total daily dose (TDD) 100 mg; 0.33-0.54 m2: 100 mg per dose, TDD 200 mg; 0.55-0.76 m2: 150 mg per dose, TDD 300 mg; 0.77-0.97 m2 2: 200mg per dose, TDD is 400mg; 0.98-1.19m2: 250mg per dose, TDD is 500mg; 1.2-1.41m2: 300m per dose g, TDD is 600mg; 1.42-1.63m2: 350mg per dose; TDD is 700mg; ≥1.64m2: 400mg per dose, TDD is 800mg.

If the patient develops abnormalities after taking nilotinib, such as QT interval prolongation, bone marrow suppression, etc., the medication should be adjusted in a timely manner under the guidance of a doctor. Avoid concomitant use of strong CYP3A4 inhibitors. If treatment with any of these drugs is necessary, interrupt treatment with nilotinib.

The original drug Nilotinib is marketed in China under the name Nilotinib and is covered by medical insurance, but reimbursement is limited to patients who meet the indications. SpecificationsThe price of 150 mg*120 pills per box may be around RMB 9,000. The price of the Indian version of the original drug 150 mg*28 pills per box of 150 mg*28 pills sold overseas may be around RMB 1,000 (the price may fluctuate due to the exchange rate). The ingredients of the original medicine sold domestically and abroad are basically the same. There is currently no generic version of Nilotinib on the market. For more drug information and specific prices, please consult the medical consultant of YaDe.