Chinese instructions for Mosunetuzumab

1. Indications:

Motuzumab is a drug used to treat specific types of malignant tumors, mainly for the following conditions:

Diffuse largeBcell lymphoma (DLBCL): Motuzumab is indicated for the treatment of adults with refractory or relapsed diffuse largeBcell lymphoma.

2. Mechanism of action:

The mechanism of action of motuzumab is based on its bispecific antibody structure. It targets two different proteins simultaneously, CD3 and CD20. Specifically, motuzumab works by:

1.Connecting T cells and B cells: motuzumab binds CD3 is present in T Antigens on pan> cells and CD20antigens present on B cells, thereby guiding T cells to the vicinity of cancer cells.

2. Activation of immune cells: Once T cells come into contact with CD20-positive malignant B cells, they release toxic substances, such as perforin and cytotoxic enzymes, leading to cancer cell death.

3.Enhance immune response: Motuzumab can also activate natural killer cells (NK cells) and other immune cells, enhancing the immune system's attack on malignant B cells.

3. Pharmacology:

1.Absorption and Distribution: Motuzumab is usually administered intravenously. It is rapidly distributed to various tissues and organs in the body, including tumor tissue.

2.Metabolism and excretion: The metabolism and excretion of motuzumab is not fully understood, but it may be metabolized in the liver and excreted in the kidneys.

4. Dosage and usage:

The dosage and usage of motuzumab should be determined by a professional doctor based on the patient’s specific situation, which usually includes the following aspects:

1.Route of administration: Motuzumab is administered by intravenous injection.

2.Initial dose: Typically in the first and second cycles of treatment, patients receive a lower initial dose to reduce the risk of adverse reactions.

3.Subsequent dosage: Based on the patient's tolerance and treatment response, the doctor will decide on subsequent dosage adjustments and the duration of the treatment cycle.

5. Side effects:

The use of motuzumab may be associated with the following side effects, and patients should be closely monitored and reported during treatment: Fever and chills, Nausea and vomiting, Fatigue and weakness, Headache, Injection site reactions (such as redness, swelling, pain), Hypotension, etc.

6. Warnings and precautions:

Patients and physicians need to pay close attention to the following warnings and precautions when using motuzumab:

1.Allergic reactions: During treatment, severe allergic reactions may occur, including shortness of breath, skin urticaria, hypotension, etc. This needs to be reported to a doctor immediately.

2.Risk of infection: Motuzumab may reduce the function of the immune system and increase the risk of infection. Patients should avoid contact with known sources of infection and undergo regular surveillance for infection.

3.Leukopenia: A decrease in white blood cells may occur during treatment, increasing the risk of infection. The doctor will monitor the patient's blood cell count and take necessary steps.

4.Tumor lysis syndrome: Treatment may cause tumor cells to lyse, releasing a large amount of intracellular substances, which may lead to problems such as impaired renal function.

7. Contraindications:

The use of motuzumab may be limited by the following conditions:

1.Patients with known allergy to this drug or its ingredients.

2.Pregnant and lactating women, as motuzumab may cause harm to the fetus or infant.

8. Drug interactions:

During treatment with motuzumab, patients should inform their doctors of all medications they are taking, as some drugs may interact with motuzumab, affecting efficacy or increasing the risk of adverse reactions.

9. Medication for special groups:

In elderly patients, patients with impaired hepatic or renal function, and children, the motuzumab dose or treatment plan may need to be adjusted. Your doctor will make an assessment on an individual basis.

Please note that the above information is for reference only, and specific medication guidance should be determined by a professional doctor based on the patient's specific situation and disease status. Always talk to your doctor before using motuzumab or any other medicine, and follow his or her recommendations.

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