What are the side effects of Neratinib?

Neratinib, marketed under the trade nameNerlynx, is a tyrosine kinase inhibitor anticancer drug used to treat breast cancer, which targets the epidermal growth factor receptor ( EGFR), HER2, and human epidermal growth factor receptor 4 (HER4)-positive cancers exhibit antitumor effects that prevent phosphorylation of tyrosine residues on the receptors and reduce oncogenic signaling through the mitogen-activated protein kinase and Akt pathways.

In clinical studies of extended adjuvant treatment of early breast cancer, the most common adverse reactions of neratinib (≥5%) were diarrhea, nausea, abdominal pain, fatigue, vomiting, rash, stomatitis, decreased appetite, muscle cramps, indigestion, elevated AST or ALT, nail abnormalities, dry skin, abdominal distension, nose bleeding, weight loss and urinary tract infection. In clinical studies of advanced or metastatic breast cancer, the most common adverse reactions in the plus capecitabine group were diarrhea, nausea, vomiting, decreased appetite, constipation, fatigue/asthenia, weight loss, dizziness, back pain, joint pain, urinary tract infection, upper respiratory tract infection, abdominal distension, renal impairment, and muscle cramps.

NeratinibThe original drug is marketed in China as neratinib maleate tablets and is covered by Class B medical insurance, but reimbursement is limited to patients who meet the indications. SpecificationsThe price of each box of 40mg*180 tablets may be around 7,000 yuan. Generic drugs of neratinib are also sold overseas. The drug ingredients are basically the same as those of the original drug. The price of 40mg*180 tablets produced by Bangladesh pharmaceutical factory may be around 4,000 yuan per box (the price may fluctuate due to the exchange rate). For more information about overseas drugs and specific prices, please consult Yaode Medical Consultant.