How to take Neratinib

Neratinib (Neratinib) is approved for the extended adjuvant treatment of early breast cancer and the treatment of advanced or metastatic breast cancer. Neratinib may cause severe diarrhea and sequelae, such as dehydration, hypotension and renal failure. Doctors will recommend that patients should use loperamide for antidiarrheal prophylaxis while taking the first dose of neratinib.

(1) Extended adjuvant treatment of early breast cancer: The recommended dose of neratinib is 240 mg (6 tablets), taken orally once a day with food, until disease recurrence or up to one year.

(2) Advanced or metastatic breast cancer: The recommended dose of neratinib is 240 mg (6 tablets) taken orally once daily with food on days 1-21 of a 21-day cycle, plus capecitabine (750 mg/m2 orally twice daily) on days 1-14 of a 21-day cycle until disease progression or unacceptable toxicity occurs.

(3) Dose escalation: For patients with early-stage breast cancer and metastatic breast cancer, consideration may be given to increasing the dose of neratinib by two weeks rather than starting at a dose of 240 mg daily. The dose in week 1 (days 1-7) is 120 mg daily; the dose in week 2 (days 8-14) is 160 mg daily; the dose in weeks 3 and beyond is 240 mg daily.

NeratinibThe original drug is marketed in China as neratinib maleate tablets and is covered by Class B medical insurance, but reimbursement is limited to patients who meet the indications. SpecificationsThe price of each box of 40mg*180 tablets may be around 7,000 yuan. Generic drugs of neratinib are also sold overseas. The drug ingredients are basically the same as those of the original drug. The price of 40mg*180 tablets produced by Bangladesh pharmaceutical factory may be around 4,000 yuan per box (the price may fluctuate due to the exchange rate). For more information about overseas drugs and specific prices, please consult Yaode Medical Consultant.